中文摘要：

目的探讨中医药防治头颈部肿瘤放疗后放射性口咽黏膜炎（radioactive oropharyngeal mucositis,ROM）的临床疗效。方法选择2012—2015年收治的头颈部肿瘤放疗的患者60例,分为中药治疗组和对照组,每组30例。两组均给予常规治疗,中药治疗组在常规治疗基础上加服按照中医辨证配制的方药水煎剂。观察两组放疗结束后ROM的发生情况、唾液表皮生长因子（epidermal growth factot,EGF）变化水平、中医证候变化情况、卡氏（KPS）和疼痛数字评价量表（numerical rating scale,NRS）评分。结果两组均发生ROM,但中药治疗组病变程度轻于对照组,各中医证候发生率均明显低于对照组（P〈0.05）。放疗后两组EGF水平和KPS评分较放疗前下降,但中药治疗组均高于对照组（P〈0.05）;放疗后两组NRS评分高于放疗前,但中药治疗组低于对照组（P〈0.05）。结论中医药防治ROM疗效确切,安全性高。

英文摘要：

Objective To investigate the effect of traditional Chinese medicine（ TCM） in prevention and treatment of radioactive oropharyngeal mucositis（ ROM） in patients with head and neck neoplasms. Methods A total of 60 head and neck neoplasms patients were divided into TCM treatment group（ n = 30） and control group（ n = 30）. All the patients received conventional therapy,and the TCM treatment group was added with TCM medicine decoction. The incidence rates of ROM,level changes of salivary epidermal growth factor（ EGF）,changes of TCM symptoms,KPS and numerical rating scale（ NRS） scores were observed in the two groups respectively after the radiotherapy. Results All the patients suffered from ROM,but the severity was significantly lighter,and the incidence rate of TCM symptoms was significantly lower in TCM group than those in the control group（ P〈0. 05）. After the radiotherapy,the values of salivary EGF level and KPS score were decreased in the two groups compared with those before the radiotherapy,but the values of TCM treatment group were higher than those in the control group（ P〈0. 05）; the NRS scores were increased in the two groups compared with those before the radiotherapy,but the score of TCM treatment group was lower than that of control group（ P〈0. 05）. Conclusion Traditional Chinese medicine is effective in prevention and treatment of ROM with high safety.