中文摘要：

目的建立人食管癌及小鼠不同移植瘤模型，比较放、化疗对小鼠的不同肿瘤模型的抑制作用。方法动物模型建立24h后，将不同肿瘤细胞（淋巴瘤、肉瘤S180、肝癌H22、白血病L1210）的荷瘤IRM-2近交系小鼠随机分为对照组、照射组、环磷酰胺组，每组10只。环磷酰胺组于接种隔日腹腔注射环磷酰胺（25mg／kg）1次，0．2ml／只，共4次。照射组于接种后第4天进行全身1Gy照射，每日1次，连续5d。将食管癌EC901荷瘤裸鼠随机分为对照组、照射组、5．氟尿嘧啶组，每组5只。照射组于接种后第4天和第8天对肿瘤局部进行2Gv照射，5-氟尿嘧啶组于接种后隔日腹腔注射5-氟尿嘧啶（25mg／kg）1次，0．2m1]只，共4次。所有小鼠于第12天处死，解剖瘤块称重，计算抑瘤率。结果裸鼠及IRM-2近交系小鼠皮下移植瘤模型的成瘤率均为100％，放疗对淋巴瘤、肉瘤S180、肝癌H22、白血病L1210荷瘤小鼠的肿瘤有显著的抑制作用，抑瘤率分别为34．57％、32．69％、31-31％和18．32％，与对照组比较差异有统计学意义（t=4．130、3．222、3．581和2．713，P分别为〈0．01、〈0．01、〈0．01、〈0．05）。放疗对食管癌EC901的抑瘤率为22．99％，但与对照组比较差异无统计学意义（拉1．235，P〉0．05）。化疗对淋巴瘤、肉瘤S180、肝癌H22、白血病L1210、食管癌EC901荷瘤小鼠的抑瘤率分别为74．47％、72．59％、69．12％、77．53％和56．32％，与对照组比菠差异有统计学意义（t=12．694、12．208、7．223、11．964和5．266，P均〈0．01）。结论放、化疗对小鼠的不同肿瘤模型均有抑制作用。由于小鼠的品系和瘤源不同，对放、化疗的敏感性也存在差异。

英文摘要：

Objective To set up the models of human esophageal cancer in nude mice and the models of different xenograft tumors in IRM-2 mice, observe the effects of chemotherapy and radiotherapy on the tumors. Methods Twenty-four hours after setting up the models, all the mice carrying tumors including lymphoma, hepatic carcinoma H22, leukemia L1210 and sarcoma S180 were randomly divided into 3 groups： control group, radiotherapy group and cyclophosphamidum group, 10 mice per group. Mice in cyclophos- phamidum group were injected cyclophosphamidum （25 mg/kg） by intraperitoneal 4 times every other day; mice in radiotherapy group were given total body irradiation at the fourth day and last for 5 days. Mice with human esophageal cancer were randomly divided into 3 groups： control group, radiotherapy group and 5-fluo- rouracil group, 5 mice per group. Mice in radiotherapy group were given local body irradiation at the fourth day and the eighth day. Mice in 5-fluorouraeil group were injected 5-fluorouraeil （25 mg/kg） by intraperi- toneal 4 times every other day. All the mice were killed at the twelfth day and the rates of tumor inhibition were calculated. Results The tumor inhibitory rates of IRM-2 mice in radiotherapy group were 34.57% （lymphoma）, 32.69%（sarcoma S 180）, 31.3 l%（hepatic carcinoma H22） and 18.32%（leukemia L1210） respec- tively, and there were significant difference compared with control group（t=4.130, 3.222, 3.581 and 2.713, P〈0.OI, 〈0.01, 〈0.01 and 〈0.05）. The tumor inhibitory rates of nude mice with human esophageal cancer in radiotherapy group was 22.99%, but there was no significant difference compared with control group（t= 1.235, P〉0.05）. The tumor inhibitory rates in radiotherapy group were 74.47%（lymphoma）, 72.59%（sarcoma S180）, 69.12%（hepatic carcinoma H22）, 77.53%（leukemia L1210） and 56.32%（human esophageal cancer）, and there were significant difference compared with control group（t =12.694, 12.208, 7.223, 11.964 and 5.266, all P〈0.01?