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肺癌患者谷胱甘肽S-转移酶P1基因Ile105Val多态性分析
  • 期刊名称:郑州大学学报 医学版,2006,41(3): 448-451
  • 时间:0
  • 分类:R734.2[医药卫生—肿瘤;医药卫生—临床医学]
  • 作者机构:[1]郑州大学公共卫生学院劳动卫生学及毒理学教研室,郑州450052, [2]河南省胸科医院内六科,郑州450003
  • 相关基金:国家自然科学基金资助项目30571552;教育部“211工程”重点学科研究项目资助
  • 相关项目:基于模糊神经网络的肺癌早期预警预报系统的研究
中文摘要:

目的:分析肺癌患者谷胱甘肽S-转移酶P1(GSTP1)基因Ile105Val单核苷酸多态性。方法:采用病例.对照研究方法,以聚合酶链反应-限制性片段长度多态(PCR-RFLP)技术,检测121例正常对照和121例肺癌患者GSTP1基因Ile105Val多态性基因型分布,并比较各基因型与肺癌易感性的关系。结果:肺癌患者中,携带GSTP1突变等位基因的基因型Ile/Val+Val/Val的频率为51.2%,高于对照组的33.1%(P=0.004);至少携带一个Val等位基因的个体发生肺癌风险是Ile/Ile基因型个体的2.13倍(95%CI1.27-3.58),且病理分型分析显示风险增加主要在鳞癌组。经吸烟分层后,仅增加吸烟者的风险。结论:GSTP1基因Ilel05Val多态可能与中国人肺癌易感性有关,可用于对肺癌易感个体的预警和预防。

英文摘要:

Aim:To investigate the glutathione-S-transferase P1 polymorphism in patients with lung cance,Methods:A case-control study of 121 lung cancer patients and 121 control subjeets (matched for sex ,age)was conducted to investigate the poylmorphism of GSTP1 gene Ile105Val in lung cancer.Genotyping was detected using PCR hased restriction fragment length polymorphism technique(PCR-RFLP).The association between this genetic polymorphism and the risk of lung cancer was examined by a multivariate analysis.Results:The frequency of Ile/Val+Val/Val genotypes in the case group (51.2%) was significantly higher than that in the control group(33.1%).with the OR fro lung cancer of 2.13 (95% CI 1.27-3.58).The risk of lung cancer only rised in the smokers.Conclusion:The polymorphism of GSTP1 may ussociate with the risk of lung carecioma.

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