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中文摘要：
目的评价临床疾病活动指数（CDAI）、简化疾病活动指数（SDAI）同疾病活动指数28（DAS28），对类风湿关节炎（RA）疾病活动性的评估价值。方法连续纳入200例RA患者，评估每例RA患者的关节肿胀数（SJC）、关节压痛数（TJC）、患者对病情的总体评估（PGA）、医生对病情的总体评估（PhGA）、健康评估问卷（HAQ），检测红细胞沉降率（ESR）、C反应蛋白（Cap），计算DAS28、CDAI、SDAI。用Pearson相关分别分析DAS28、CDAI、SDAI与上述任意指标的相关性。按DAS28、CDAI、SDAI各活动分期截止点将200例RA患者分类，记录各活动期患者例数，用Kappa值描述CDAI与SDAI的内部一致性，并用Kappa值分别描述CDAI、SDAI与DAS28的内部一致性。以DAS28为参照标准，用ROC曲线描述CDAI和SDAI划分RA的缓解／低度和中／重度的区分效能。结果200例RA患者的CDAI（17．2±11．1）、SDAI（19．1±11．6）与DAS28（4．3±1．5）均呈正相关（r=0．876，0．861，P〈0．05）。二者及DAS28与HAQ（0．6±0．7）亦均呈正相关（r=0．522，0．523，0．482，P〈0．05）。比较CDAI与SDAI，二者Kappa值为0．777，进一步比较CDAI、SDAI与DAS28的Kappa值分别为0．482，0．394。以DAS28作为参照标准，CDAI、SDAI的ROC曲线下面积分别为0．906、0．888。结论CDAI、SDAI同目前国际公认的DAS28一样，亦可以很好地评估RA疾病活动性，且二者与HAQ的相关性高于DAS28。相比于SDAI，CDAI缺少炎性指标，但二者一致性极好，且CDAI与DAS28的内部一致性优于SDAI与DAS28。此外，CDAI划分RA的缓解／{氐度和中／重度的效能稍高于SDAI。CDAI更简便、快捷、准确，适用于RA的日常评估。
英文摘要：
Objective To compare the clinical disease activity index （CDAI） and simplified disease activity index （SDAI） as well as disease activity score 28 （DAS28） by assessing the activity of rheumatoid arthritis （RA） and to explore which one is better. Methods Two hundred RA patients were enrolled. Swelling joint counts （SJC）, tenderness joint couuts（TJC）, patient＇s and doctor＇s global assessment of disease activity based on visual analogue scale （PGA, PhGA）, health assessment questionnaire （HAQ） were recorded and the erythrocyte sedimentation rate （ESR）, C reaction protein （CRP） of each patient were tested. DAS28, CDAI, SDAI of all patients were calculated for all patients. Statistical analysis was carried out by Pearson correlation for the association between DAS28 and the above parameters, as well as CDAI, and SDAI. We created 4 patient groups based on DAS28, CDA! and SDAI ranks and used kappa statistics to assess the level of overall agreement of different disease activity categories between any of the two indices above for individual patients. We assessed the discriminating validity using receiver operating characteristic （ROC） curve analysis to compare the ability of the CDAI and SDAI to discriminate between patients with remission, low andmoderate, high disease activity. Results Of all the patients, CDAI（17.2±11.1） and SDAI（19.1±ll.6） were correlated with DAS28 （4.3±_1.5）, the correMion coefficients were 0.876,0.861 （P〈0.05） respectively. CDAI and SDAI were correlated with HAQ （0.6±0.7）, as well as DAS28. The correlation coefficients were 0.522, 0.523, and 0.482 （P〈0.05）. The Kappa of CDAI and SDA was 0.777. The Kappa of CDAI and DAS28, SDAI and DAS28 were 0.482, 0.394. The areas under ROC of CDAI and SDAI were 0.906, 0.888 if DAS28 was used as the gold standard. Conclusion CDAI and SDAI as well as DAS28 can be used to assess the activity of RA and both are better correlated with HAQ than DAS28. Though there is no CRP in CDAI when comp
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