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Pedigree transmission disequilibrium test for quantitative traits in farm animals
  • ISSN号:0253-9772
  • 期刊名称:《遗传》
  • 时间:0
  • 分类:S511[农业科学—作物学] TH113.25[机械工程—机械设计及理论]
  • 作者机构:[1]Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of Agriculture, National Engineering Laboratory for AnimalBreeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
  • 相关基金:supported by the Scientific Research Foundation for Returned Scholars,Ministry of Education of China;National Natural Science Foundation of China(30800776);the Program for Changjiang Scholar and Innovation Research Team in University(IRT1191);the Beijing Science and Technology Ministry Project(Z101105000810001);the"948"of Ministry of Agriculture Project,China(2011-G2A)
中文摘要:

一般家谱在农场动物是很普通的,并且在国内种类的 SNP 的大面板的最近的可获得性为量的特点地位于变化下面的变化把新动量给了搜索。在这份报纸,我们建议了一条新传播不平衡测试途径,叫了家谱传播不平衡测试,它在农场动物处理一般家谱和量的特点。与存在家谱不平衡测试(太平洋夏季时间) 和一般线性基于模型的方法 QTDT 相比,我们的途径与更高的力量和更低的类型更好表现了我错误,特别在量的特点地点(QTL ) 效果是小的情形。我们也在选择 genotyping 设计调查了我们的途径的申请。我们的模拟研究显示在建议家谱传播不平衡测试实现选择 genotyping 策略是嘴巧的。当当在家谱的所有个人是 genotyped 时,仅仅在二条尾巴的个人的某比例与它的表演相比是 genotyped 时,我们发现我们的途径同等地表现了很好或更好。

英文摘要:

General pedigrees are very common in farm animals,and the recent availability of large panels of SNPs in domestic species has given new momentum to the search for the mutations underlying variation in quantitative traits.In this paper,we proposed a new transmission disequilibrium test approach,called the pedigree transmission disequilibrium test,which deals with general pedigrees and quantitative traits in farm animals.Compared with the existing pedigree disequilibrium test (PDT) and general linear model-based method QTDT,our approach performed better with higher power and lower type I error,especially in scenarios where the quantitative trait locus (QTL) effect was small.We also investigated the application of our approach in selective genotyping design.Our simulation studies indicated that it was plausible to implement a selective genotyping strategy in the proposed pedigree transmission disequilibrium test.We found that our approach performed equally well or better when only some proportion of the individuals in the two tails were genotyped compared with its performance when all the individuals in the pedigree were genotyped.

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期刊信息
  • 《遗传》
  • 中国科技核心期刊
  • 主管单位:中国科学院
  • 主办单位:中国遗传学会
  • 主编:张永清
  • 地址:北京朝阳区北辰西路1号院中国科学院遗传发育所
  • 邮编:100101
  • 邮箱:yczz@genetics.ac.cn
  • 电话:010-64807669
  • 国际标准刊号:ISSN:0253-9772
  • 国内统一刊号:ISSN:11-1913/R
  • 邮发代号:2-810
  • 获奖情况:
  • 中国自然科学核心期刊,《CAJ-CD》执行优秀奖,2008年12月获“中国精品科技期刊”证书和北京市印...
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  • 美国化学文摘(网络版),英国农业与生物科学研究中心文摘,荷兰文摘与引文数据库,美国生物医学检索系统,美国生物科学数据库,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊(2004版),中国北大核心期刊(2008版),中国北大核心期刊(2011版),中国北大核心期刊(2014版),中国北大核心期刊(2000版)
  • 被引量:23270