中文摘要：

目的 研究中国汉族正常成人视束MRI形态特征,为建立中国标准脑提供视束形态学测量数据.方法 采用全国多中心临床研究形式,选取18～70岁健康中国成年志愿者共1000名,按照年龄18～30、31～40、41～50、51～60、61～70岁分为A、B、C、D、E组,每组男、女各100例.所有受试者均行3D磁化强度预备梯度回波序列T1WI采集容积数据,再采用多基线技术最佳化显示视束结构及形态,测量视束各径线：视束脑池段横径（TD1）、视束大脑脚周段横径（TD2）、视束起点池段到大脑脚周段长度（L）、视束夹角（AOT）,以及视束从前到后5个断面上下径（H）：视束起始点层面上下径（H1）、视束池-前联合层面上下径（H2）、视束乳头体层面上下径（H3）、视束室间孔层面上下径（H4）、视束近外侧膝状体节段上下径（H5）.不同性别及年龄分组的视束测量值比较采用协方差分析,左、右视束侧别的比较采用配对样本t检验分析.结果 （1）男、女性别间视束径线比较：男性左、右侧L分别为（11.69±1.45）、（11.56±1.44）mm,女性左、右侧L分别为（10.58±1.29）、（10.40±1.34）mm,男性左、右侧H1分别为（2.56±0.28）、（2.60±0.29）mm,女性左、右侧H1分别为（2.57±0.31）、（2.63±0.32）mm,以上测量指标在性别间差异有统计学意义（F值分别为22.236、29.703、11.130、7.805,P值分别为0.000、0.000、0.000、0.005）,男性L大于女性,男性H1小于女性;余测量径线性别差异无统计学意义（P值均〉0.05）;（2）年龄分组比较：左、右侧TD1、右侧TD2在5个年龄分组的值分别为：左TD1为（4.64±0.51）、（4.64±0.57）、（4.55±0.58）、（4.39±0.53）、（4.36±0.58）mm;右TD1为（4.84±0.53）、（4.80±0.60）、（4.77±0.65）、（4.60±0.59）、（4.57±0.59）mm;右TD2为（3.33±0.45）、（3.34±0.41）、（3.33±0.36）、（3.23±0.38）、（3.23±0.39）mm,在年龄分组?

英文摘要：

Objective To explore the morphological characteristics of optic tracts in healthy Chinese Han adults on the high-resolution MRI and fill the database of Chinese standard brain with morphological data of optic tracts.Methods Cerebral MRI scans with T1 WI 3D MPRAGE sequence of 1000 healthy Chinese volunteers from 15 hospitals were divided into five stages, ranging in age from 18 to 70.With the technique of multi-baseline, structure and morphology of optic tracts were displayed optimally on the images with multiplanar reconstruction.Data were measured as following： transverse distance of the cisternal optic tract （TD1） and peri-crural optic tract （TD2）, length from the cisternal optic tract to the peri-crural optic tract （L） ,angle between optic tract（AOT） and height of optic tract from its first segment to plane of anterior commissure （H） including H1, H2, H3, H4 and HS.The measurements of optic tracts between sexualities and among age groups were compared by anasis of covariance; those among five age groups were compared pairwisedly by least significant difference analysis （LSD）; and the differences of measurements between left and right optic tracts were analyzed using paired t test.Results （1） Comparisons of optic tract structures between male and female： the mean optic tract length of male [（11.69±1.45）,（11.56±1.44） mm] was significant longer than that of female [（10.58±1.29）,（10.40±1.34） mm] （F=22.236, 29.703, P=0.000）; the mean H1 of male [（2.56±0.28）,（2.60±0.29） mm] and female [（2.57±0.31 ）, （2.63±0.32） mm] were significantly different （ F =11.130,7.805, P = 0.000, 0.005）.No significant differences of the other measurements were found between male and female （ P 〉 0.05 ）.（2） Comparisons among age groups： among 5 age groups, TD1 of both sides [left TD1 ：（4.64±0.51 ）, （4.64±0.57）, （4.55±0.58）, （4.39±0.53）, （4.36±0.58）mm;right TD1 ：（4.84±0.53） ,（4.80±0.60）, （4.77±0.65）, （4.60