中文摘要：

目的 测量中国正常汉族成人岛叶体积,分析岛叶体积与年龄、性别、体重及颅脑容积的相关性,为建立中国标准脑提供可靠数据.方法 选择健康汉族成人志愿者1000名,按照年龄18～30、31～40、41～50、51～60、61～70岁分为A、B、C、D、E组,每组男、女各100名.所有受试者均行3D磁化强度预备梯度回波序列T1WI,应用3D体积分析软件手工勾绘ROI,测最健康中国成年人岛叶的体积,并进行标准化处理.双侧岛叶体积间比较采用配对t检验分析,不同性别间岛叶体积比较用两独立样本t检验分析,不同年龄段之间进行单因素方差分析.结果 标准化前1000名受试者左、右侧岛叶体积分别为（7764±1165）、（7387±1128）mm^3,标准化后为（8413±1201）、（7871±1140）mm^3,左侧大于右侧（t值分别为-10.565、-16.014,P值均〈0.01）.标准化前男性左、右侧岛叶体积分别为（8146±1181）、（7735±1113）mm^3,女性左、右侧岛叶体积分别为（7393±1022）、（7050±1038）mm^3,男性左、右侧岛叶体积均大于女性（t值分别为10.934、9.945,P值均〈0.01）.标准化后男性左、右侧岛叶体积分别为（8779±1230）、（8224±1081）mm^3,女性左、右侧岛叶体积分别为（8043±1054）、（7515±1091）mm^3,男性左、右侧岛叶体积均大于女性（t值分别为4.858、4.632,P值均〈0.01）.标准化前A、B、C、D、E组左侧岛叶体积分别为（8268±1221）、（8067±1107）、（7869±1109）、（7603±1111）、（6997±934）mm^3,右侧岛叶体积分别为（8028±1156）、（7636±1075）、（7294±986）、（7249±1068）、（6717±916）mm^3,5组间左、右侧岛叶体积差异均有统计学意义（F值分别为-0.361、-0.337,P值均〈0.01）.标准化后A、B、C、D、E组左侧岛叶体积分别为（9093±1105）、（8679±965）、（8810±1136）、（8202±980）、（7273±940）mm^3,右侧岛叶体积分别为（8694±1005）、（8136±1100）、（8034±910）?

英文摘要：

Objective To explore the normal range of the insula volume of Chinese adults of the Han nationality and its relationship with age, which provide morphological data for the construction of database for Chinese Standard Brain.Methods This is a clinical multi-center study.One thousand Chinese healthy volunteers （age range = 18 to 70） recruited from 16 hospitals were divided into 5 groups, i.e.,Group A （ age range = 18 to 30）, B （ age range = 31 to 40 ）, C （ age range = 41 to 50 ）, D （ age range =51 to 60）, and E （age range =61 to 70）.Each group contained 100 males and 100 females.All of the volunteers were scanned by MR using T1 weighted three-dimensional magnetization prepared rapid acquisition gradient echo sequence.After three dimension data reconstruction, the volumes of bilateral insula were manually measured.The volume of bilateral insula were compared by paired sample t test.The insula volumes were compared between male and female by independent sample t test, and the differences among 5 age groups were compared by one-way ANNOVA.The relationship between the volumes of insula and age,sex or cerebral volume were analyzed using bivariate correlation, respectively.Results The left snd right side volume of insula before standarized were （7764±1165） and （7387±1128） mm3 respectively, after standarized were （8413±1201 ） and （7871±1140） mm^3 respectively.The left insula volume were significant larger than that of right（t = - 10.565, - 16.014,P 〈0.01 ）.The left and fight volume of insula were （8146±1181 ） and （7735±1113） mm^3 for male, and （7393±1022） mm^3 and （7050±1038） mm3for female.The left and right insula volumes for male were larger than the female＇s（t = 10.934,9.945 ,P 〈0.01 ）.The left and right insula volume of male after standarized were （8779±1230 ） and （8224±1081 ）mm^^3, female were （8043±1054） and （7515±1091 ） mm^3 ,the left and right insula volume of male were larger than the female＇s （ t = 4.858,4.632,