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中文摘要：
以α-溴代四乙酰基葡萄糖（或β-D-葡萄糖五乙酸酯）和酚为原料,经2步反应合成了15个新的β-D-吡喃型葡萄糖酚苷类天然产物类似物,采用质谱（MS）及核磁共振（NMR）等手段对其结构进行了表征.生物活性测定结果表明,化合物8a和10a对丙型肝炎病毒（HCV）有一定的抑制作用,它们的EC50值分别为21和9.4μmol/L,CC50值分别为150.4和145.9μmol/L.
英文摘要：
Phenolic β-D-glucopyranosides exist widely in nature and exhibit many important physiological activities.For example,gastrodia isolated from Pholidota chinensis Lind1.has such a sketch and play an important bioactivity on nerve system.Recently,we found another phenolic β-D-glucopyranoside from the Pulicaria insignis which had definite anti-HCV activity.Based on the results achieved in our research group,we tried to design and synthesize series of phenolic β-D-glucopyranosides to wish to find new and better bioactive compounds used in anti-HCV study.Fifteen novel natural analogues of phenolic β-D-glucopyranosides were synthesized from phenolic aglycones and acetobromo-α-D-glucose or β-D-glucose pentaacetate.Their structures were characterized by MS,1H NMR and 13C NMR.Preliminary anti-HCV activity tests showed that compounds 8a and 10a exhibited definite anti-viral activity,their EC50 are 21 and 9.4 μmol/L,and the CC50 of them are 150.4 and 145.9 μmol/L,respectively.
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