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中文摘要：
采用硅胶柱色谱、ODS柱色谱、Sephadex LH-20柱色谱、HPLC等分离方法对金针菇大米发酵乙酸乙酯提取物进行分离,根据理化性质和波谱数据鉴定化合物结构：鉴定了4个倍半萜,包括1个新的桉叶烷型倍半萜,3个侧柏烷型倍半萜,分别是flamvelutpenol A（1）,aquaticol（2）,enokipodin C（3）,limacellone（4）。并通过与Rh2（OCOCF3）4络合的方法确定了新化合物flamvelutpenol A（1）和limacellone（4）的绝对构型。其中化合物3具有较好的抗菌活性,对耐甲氧西林金黄色葡萄球菌和枯草芽孢杆菌的MIC值分别为12.5mg/L,25mg/L。且化合物1-4均是首次从该种真菌中分离得到。
英文摘要：
The ethyl acetate extracts of the solid culture of Flammulina velutipes was subjected to silica gel,ODS,sephadex LH-20 column chromatography and HPLC prepration.Four sesquiterpenoids have been isolated from the mycelial culture of this mushroom.One novel eudesmane-type sesquiterpenoid together with three known cuparene-type sesquiterpenoids were obtained,including flamvelutpenol A （1）,aquaticol （2）,enokipodin C （3）,and limacellone （4）.The absolute configuration of 1 and 4 were determined by forming complex with [Rh 2 （OCOCF 3） 4 ] and then applying the bulkiness rule.Compounds 3 showed strong antibacterial activity against methicillin-resistant Staphylococcus aureus and Bacillus subtilis with MIC value 12.5mg/L and 25mg/L.Compounds 1-4 were isolated from the fungus for the first time.
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