天然来源抗肿瘤活性产物是抗肿瘤药物先导化合物的重要资源。促分裂原活化蛋白激酶(MAPK)通路是细胞内重要的信号转导系统,可以调节细胞的生长、凋亡、黏附、迁移等过程,继而影响肿瘤的发生、发展、侵袭、转移,是潜在的抗肿瘤药物作用靶点之一。本文将对天然来源化合物作用于MAPK信号通路的靶点分子及生物效应进行阐述,为肿瘤的化学预防及治疗提供启发。
Natural compound is an important source of antitumor candidate agents.The mitogen-activated protein(MAP) kinase pathway can regulate the process of cell proliferation,apoptosis,attachment and migration,therefore influencing the development of tumor.Key molecules of MAPK pathway are potential targets of antitumor drugs.The paper explained the biological effects of natural products via targeting key molecules of MAPKs,and provided clues to chemoprevention and chemotherapy of cancer.