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中文摘要：
原子力显微镜有一个重要的特点，即利用其非修饰和修饰探针进行样品扫描，可以得到样品表面形貌，并获得样品表面某一特定点的力与距离的关系曲线，进而得到黏附力、键合力等数据以及样品的机械性质。目前国际上应用原子力显微镜对细胞力学特性方面的研究已经成为最热门的研究课题之一，利用原子力显微镜研究细胞形态学和力学性质，在生物医学和临床医学方面有重要研究意义。文章介绍原子力显微镜中的力曲线原理，综述了原子力显微镜在细胞黏弹性，硬度和抗原，抗体之间的相互作用力等方面的应用，并对应用力曲线分析细胞力学机械性质的应用和发展前景进行了展望。
英文摘要：
Atomic force microscope （AFM） has one important feature that it is used to scan the samples with non-modified and modified probes to obtain sample appearance, and force-distance curve at certain point, based on which the adhesion, bond force and mechanical properties of the sample can be obtained. Until recently, the application of the AFM to measure the mechanical properties of biological sample is very extensive, which is significant in biomedicine and clinical medicine. This paper introduced the force curve theory of AFM, and reviewed the application of AFM to measure the mechanical properties of biological sample including elasticity, adhesion, stiffness, the interaction between antibody and antigen of the cell. In addition, we prospected the application and development of AFM to analyze cell mechanical properties.
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