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中文摘要：
为了优化β-环糊精微球的制备工艺,采用U13＊（134）均匀设计对合成工艺优化,得出最佳合成工艺为反应温度80℃,反应时间4 h,交联剂的用量8 g,搅拌速度1000 r/min。影响微球粒径的因素：搅拌速度〉反应温度。影响产量的因素：交联剂的用量〉反应时间。最佳合成工艺下的微球表面圆整,具有较好的热稳定性。
英文摘要：
The preparation of β-cyclodextrin microspheres was optimized by using U13＊（134）uniform design.The result showed that the optimμm reaction temperature was 80 ℃,reaction time was 4 h,the amount of crosslinker was 8 g and stirring speed was 1000 r/min.The factors affecting microsphere size were stirring speed,and reaction temperature.The factors affecting yield were crosslinking agent,and reaction time.The surface of those β-CD microspheres under optimal conditions was smooth and had good thermal stability.
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