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中文摘要：
目的：研究早期使用乌司他丁治疗多发伤全身炎症反应综合征（SIRS）的效果。方法选择多发伤患者71例，分为对照组34例、观察组37例；两组均行常规对症治疗；观察组加用乌司他丁针，疗程5 d；动态观察两组入院5 d（120 h）血清炎症因子（TNF-α、IL-6、IL-8）变化及总住院时间、ICU住院时间、28 d病死率。结果血清炎症因子浓度观察组24 h内逐渐升高，而后逐步下降（P〈0.05），对照组持续升高（P〈0.05），观察组治疗后各时间段血清炎症因子值均小于对照组（P〈0.05）；观察组总住院时间、ICU住院时间明显少于对照组（P〈0.05）；但两组28 d病死率比较差异无统计学意义（P〉0.05）。结论乌司他丁可减轻多发伤患者炎症反应，缩短总住院时间、ICU住院时间，但对其死亡率无明显影响。
英文摘要：
Objective To evaluate the effect of earlier using ulinastatin for SIRS of patients with multi-injure. Methods A total of 71 patients with multi-injure were divided into two groups：the inspecting group and control group. 37,34 cas-es respectively. The two groups were treated according to the therapy guidelines of multi-injure.Besides taking the ma-noeuvres same as the contrast group, the inspecting group were added ulinastatin for 5 days;The blood concentration of inflammatory factors included Tumor necrosis factor-alpha （TNF-α）, Interleukin-6 （IL-6）, Interleukin-8 （IL-8） were measured. The days in ICU, the avarege days of stay hospital and the 28-day fatality rate were compared. Results During the first 24 h, the level of inflammatory factors in plasma of the inspecting group elevated, and after that time they decreased continuously. In control group, the level of inflammatory factors in plasma were increased continuously in the every measure times, and had a significont difference between the two groups（P〈0.05）. The days in ICU, the av-erage days of stay hospital of inspecting group were shorter than that of the contrast group（P〈0.05）. But the 28-day fa-tality rate didn’t have significant difference in the two groups （P〉0.05）.Conclusion Using ulinastatin could alleviated SIRS of patients with multi-injure, and can decrease the days in ICU and the average day of stay hospital. But it can not change the 28-day fatality rate.
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