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中文摘要：
采用谷氨酸席夫碱Ni（Ⅱ）配合物法合成L-茶氨酸。手性助剂——2-[N-（N-苄基）-脯氨酰]-氨基-二苯甲酮（BPB）、六水合氯化镍和L-谷氨酸反应，将谷氨酸的α-羧基和氨基进行同时保护，得到谷氨酸席夫碱Ni（Ⅱ）配合物；通过接肽试剂与乙胺盐酸盐反应，得到茶氨酸席夫碱Ni（Ⅱ）配合物，经酸水解后离交分离，获得L-茶氨酸，3步反应总收率为70％。手性辅基BPB可回收，回收率超过9HD％。中间产物和终产物的结构经由^1HNMR、HRMS和旋光表征。
英文摘要：
L-Theanine was synthesized via Ni （ Ⅱ ） complex of glutamic acid＇ s Schiff base. Through reacting with chiral auxiliary 2- [ N- （N＇-benzyl-prolyl） amino ] benzophenone and NiCl2, the α- carboxyl and amino groups of L-glutamic acid were co-protected as Schiff base. After amidation reaction, the complex of L-theanine＇s Schiff base was formed. Finally, L-theanine was obtained in an overall 70% yield by hydrolysis of the complex and separation of hydrolyzed mixtures in an ion exchanger column. The chiral auxiliary could be recovered in a yield exceeding 90%. Structures of intermediates and final products were characterized by ^1HNMR, HRMS and optical rotation measurements.
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