作为21世纪最具发展潜力的绿色溶剂,离子液体用于酶促合成的反应介质具有得天独厚的优势.与传统的有机溶剂相比,离子液体能够提高脂肪酶的稳定性和选择性,减少有机合成中的副反应和有毒气体的产生,后处理简单,可重复利用.参考10年来的文献,从脂肪酶催化酯类合成的常用离子液体种类、过程因素及场/反应器强化等方面进行了综述,同时展望了离子液体在未来酯类酶促合成领域的发展趋势.
As one of the most potential green solvents in the 21st century, ionic liquid has been used as reaction media in the enzymatic synthesis with enormous advantages. Compared with conventional organic media, ionic liquid could improve the stability and selectivity of lipase, reduce side reactions, eliminate toxicant organic gas, simplify the post-processing, and be renewable. Combined with the recent decade's references, this review is focused on summarizing various ionic liquids as the media, process factors, strengthening effect of field and bioreactors in the lipase-catalyzed ester synthesis process. Moreover, some future perspectives on enzymatic synthesis in ionic liquid are discussed.