学习使用了自然地发生的 crosslinking reagent-genipin 化学上修改非细胞组成的牛的心包,准备设计支架材料,和评估 genipin crosslinked 的心脏的阀门织物由调查纸巾的物理、化学的性质的牛的心包的非细胞组成的矩阵例如表面性质, crosslinking 特征,机械性质,抵抗到在 vitro 的酶的能力,和溶血测试。结果证明有 genipin 的非细胞组成的牛的心包矩阵 crosslinked 是强壮的 hydrophilicity,高 crosslinking 索引,和稳定的结构,它能维持好机械性质。作为为阀门织物工程的一种支架材料,它有宽申请前景。
The study used a naturally occurring crosslinking reagent-genipin to chemically modify acellular bovine pericardium, prepare cardiac valve tissue engineering scaffold material,and evaluated genipin crosslinked acellular matrix of bovine pericardium by investigating the physical and chemical properties of the tissues, such as the surface properties, crosslinking characteristics, mechanical properties, resistance to enzymatic capacity in vitro, and hemolysis tests. The results showed that acellular bovine pericardium matrix erosslinked with genipin was strong hydrophilicity, high crosslinking index, and stable structure, which can maintain good mechanical properties. As a kind of scaffold material for valve tissue engineering, it has wide application prospect.