中文摘要：

为软织物重建得到一种新支架材料，我们通过混合 crosslinked 准备了 XLHA-PNIPAAm 和 XLHA-MC 血管注射剂 hydrogels 哈(XLHA ) 并且二温度敏感的材料 poly 在降级不同(N-isopropylacrylamide )(PNIPAAm ) 并且 methylcellulose (MC ) 分别地。我们测试了 injectablility，酶的 biodegradability，温度敏感，结构 cytotoxicity 和二血管注射剂 hydrogels 的溶血。我们的研究成功地获得了 XLHA-PNIPAAm 血管注射剂 hydrogel 的准备条件，并且验证了那补充说非可能减解的材料 PNIPAAm 能推迟降级哈更有效地比可能减解的材料 MC。与 5 kGy 剂量放射准备的 PNIPAAm， MBAAm/NIPAAm (M/M )=0.015，单体 concentration=3% 与最慢酶的 biodegradability 生产了 XLHA-PNIPAAm。DSC 结果证明 XLHA-PNIPAAm 的温度敏感比 XLHA-MC 的更稳定。二合成 hydrogels 在 cytotoxicity 和溶血测试被限制， XLHA-PNIPAAm hydrogel 的 biocompatibility 比 XLHA-MC hydrogel 更好出现了。

英文摘要：

To get a sort of new scaffold material for soft tissue reconstruction,we have prepared XLHA-PNIPAAm and XLHA-MC injectable hydrogels through blending crosslinked HA（XLHA） and two temperature-sensitive materials differed in degradation poly（N-isopropylacrylamide）（PNIPAAm） and methylcellulose（MC）,respectively.We tested the injectablility,enzymatic biodegradability,temperature-sensitivity,structure cytotoxicity and hemolysis of the two injectable hydrogels.Our research has successfully obtained the preparation condition of XLHA-PNIPAAm injectable hydrogel,and verified that adding non-degradable material PNIPAAm can postpone the degradation of HA more effectively than degradable material MC.PNIPAAm prepared with 5 kGy dose radiation,MBAAm/NIPAAm（M/M）=0.015,monomer concentration=3% produced XLHA-PNIPAAm with slowest enzymatic biodegradability.DSC results showed that temperature-sensitivity of the XLHA-PNIPAAm was more stable than that of XLHA-MC.Two composite hydrogels were qualified in cytotoxicity and hemolysis tests and the biocompatibility of XLHA-PNIPAAm hydrogel showed better than XLHA-MC hydrogel.