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中文摘要：
汉语翘鼻子猴子(类 Rhinopithecus，亚科 Colobinae ) ，包括 R。bieti， R。brelichi 和 R。roxellana，作为有最高已知的高度的分发的非人类的首领著名。他们代表改编的一个有趣的模型有机体到极端环境压力。然而，在分子的水平的学习还都没用汉语为高高度的改编被报导翘鼻子猴子。作为导出 adipocyte 的荷尔蒙， Leptin 被相信在改编在精力动态平衡起一个重要作用到高高度环境。在现在的学习，我们定序并且比较汉语的 leptin 序列翘鼻子猴子(R。bieti 和 R。roxellana ) 与他们的低地近亲 R。avunculus 和另外的 Colobines。出人意料地，没有氨基酸变化在检验的 7 Colobinae 种类被观察，包括 2 汉语翘鼻子猴子，不在在高高度的猴子和他们的低地对应物之间的 Leptin 基因的进化模式显示差别。与以前的一在高原一种短耳野兔 Leptin 基因的适应进化发现相对照，我们的学习建议这基因不能在汉语的高高度的改编有一个重要角色翘鼻子猴子。与精力新陈代谢联系的另外的原子基因，或 mitochondrial 基因，是最可能的被涉及位于这些猴子的改编下面到寒冷和组织缺氧的分子的机制与高地环境联系了。
英文摘要：
Chinese snub-nosed monkeys （genus Rhinopithecus, subfamily Colobinae）, including R. bieti, R. brelichi and R. roxellana, are well-known as the non-human primates with the highest known altitudinal distribution. They represent an interesting model organism of adaptation to the extreme environmental stresses. However, no study at the molecular level has yet been reported for the high-altitude adaptation in Chinese snub-nosed monkeys. Leptin, as an adipocyte-derived hormone, is believed to play an important role in energy homeostasis in adaptation to high altitude environments. In the present study, we sequenced and compared leptin sequences of the Chinese snub-nosed monkeys （R. bieti and R. roxellana） with their lowland close relative R. avunculus and other Colobines. Unexpectedly, no amino acid changes were observed in the 7 Colobinae species examined, including the 2 Chinese snub-nosed monkeys, indicating no difference in the evolutionary pattern of the Leptin gene between high-altitude monkeys and their lowland counterparts. In contrast to a previous finding of adaptive evolution of Leptin gene in plateau pikas, our study suggests that this gene may not have an important role in high-altitude adaptation of Chinese snub-nosed monkeys. Other nuclear genes associated with energy metabolism, or mitochondrial genes, are most likely to be involved the molecular mechanism underlying adaptation of these monkeys to cold and hypoxia associated with the highland environment.
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