欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
研究了一条新的路线用于（S）-6-苄氧基-5-羟基-3-氧代-己酸叔丁酯的合成．以廉价、易得的R-环氧氯丙烷为起始原料，经过几步比较温和的反应得到目标化合物．在此基础上，通过对催化剂三氟化硼乙醚用量的考察以及两条反应路线优缺点的比较，找到了一条适合大规模制备的工艺路线．该路线具有收率高、原料易得、反应条件温和、产物容易分离、提纯等特点．
英文摘要：
A new way to synthesis of （S）-tert-butyl 6-benzyloxy-5-hydroxy-3-oxohexanoate was investigated. The target compound was successfully prepared via several mildly reaction processes by using R-epichlorohydrin, which is an inexpensive and easily available starting material. Through screening the amounts of BF3·Et20 and comparing two different synthetic methods, this route becomes more suitable for large-scale preparation for its high yields, mildly reacting-conditions, easily available materials and facilely purification of products.
同期刊论文项目
同项目期刊论文
Enhancement of the activity and enantioselectivity of lipase in organic systems by immobilization on
New and facile preparation of tert-butyl (3R,5S)-6-hydroxy-3,5-O-isopropylidene-3,5-dihydroxyhexanoa
Preparation of (S)-2-(2-chloro-1-hydroxyethyl)thiophene by lipase-catalyzed resolution in organic ph
期刊信息
位置：