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中文摘要：
木糖异构酶（xylose Isomerase，XI）（EC5．3．1．5）催化D-木糖到D-木酮糖及D-葡萄糖到D-果糖的异构化反应，是目前高果糖浆工业生产的关键酶．近年来，随着能源危机和环境污染的日益严重，利用可再生木质纤维素中的木糖已成为研究热点．自然界微生物体内对于木糖的利用主要有两条途径。
英文摘要：
Xylose isomerase from Thermus thermophilus is widely used in the production of high-fructose corn syrup and the construction of xylose via recombinant strains. In this paper, the positions of Mg ions and xylitol in 1BXB were established by structure analysis, molecular docking and computing. The Complex of 1BXB with xylitol was modeled and analyzed. Comparing the structure of 1BXB complex with 1SSN, it was found that the overall structure of them showed a high similarity. The residues around xylitol were highly conserved in xylose isomerase, and the orientation and positions of xylitol were very similar in both structures. The coor- dination bonds formed between Mgl and 02 or 04 of xylitol stabilized the conformation of xylitol at the active site of 1BXB.
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