中文摘要：

目的：研究玉米须纯化黄酮的抗炎作用及急性毒性试验．方法：通过乙醇溶剂提取、AB-8树脂纯化，采用二甲苯致小鼠耳廓肿胀、蛋清致大鼠足跖肿胀试验，观察玉米须黄酮的抗炎活性；通过急性毒性试验评价其安全性．结果：小鼠耳廓肿胀实验中，阳性对照组抑制率为63．94％，玉米须黄酮低、中、高剂量组抑制率分别为15．49％、39．33％、50．42％，中、高剂量具有显著性（P〈0．05）；大鼠足跖肿胀实验中，阳性对照组抑制率为83．33％，玉米须黄酮低、中、高剂量组的抑制率分别为22．22％、61．11％、77．78％，中、高剂量组有极显著抑制作用（P〈0．01）．结论：玉米须黄酮具有抗炎作用．急性毒性试验中，未发现明显中毒症状，也无一例死亡，说明玉米须纯化黄酮属实际无毒物质．

英文摘要：

Objective ：To compare the anti-inflammatory effect of purified flavonoids from corn silk （PFCS）and its safety.Methods：The anti-inflammatory effect based on dimethylbenzene-induced ear edema in mice tests and egg white-induced foot edema in rats tests. Safety was studied by acute toxicity tests. Results：Ear edema test showed that the inhibition rates of low,medium and high dose groups were 15.49%,39.33%,50.42%,the inhibition rate of positive control group was 63.94%;Foot edema test shows that the inhibition rates of low, medium and high dose groups were 22.22% ,61.11% ,77.78%.The inhibition rate of positive control group was 83.33%.Flavonoids mid-dose group and high-dose group significantly inhibit mouse ear edema （P〈0.05） and rats paw edema （P〈 0.01 ）. Conclusion： Purified flavonoids from corn silk had anti-inflammatory effect. According to acute toxicity flavonoids are a non-toxic grading , the obvious toxic reaction and death were not found in test.The purified substances actually.