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中文摘要：
奶牛乳腺炎导致奶牛产奶量下降,奶品质降低,甚至奶牛的早期淘汰,对奶牛业造成巨大危害。传统抗生素治疗乳腺炎花费大,治疗效果不确定,且易导致细菌耐药及抗生素残留问题。乳腺炎防治新制剂乳酸链球菌素、Aegis溶菌酶、溶葡萄球菌酶,分别针对病原菌细胞膜、骨架、生物膜而发挥治疗作用;CpGDNA有助于激活机体天然免疫系统;血小板浓缩液不仅具有抗菌作用且可促进乳腺组织修复。在乳腺炎治疗新策略方面,应用激素可调控乳腺细胞分泌及修复能力;另外,调控乳腺细胞相关信号通路及中性粒细胞可控制乳腺炎症反应,达到预防和治疗乳腺炎的目的。
英文摘要：
Dairy cow mastitis causes great harm to the dairy industry including decreased milk yield and milk quality, even the early elimination of dairy cows. The traditional treatment costs is great and uncertain, which is easy to cause bacterial resistance and antibiotic residues. The new preparations including Nisin, Aegis lysozyme and lysostaphin are targeting for cell membrane, skeleton, biofilms of the pathgens, re- spectively. CpG-DNA induces the hostrs nature immune response. Platelet concentration liquid not only produces antibacterial effects,but also promotes tissue repair. It is a scientific and efficient way to prevent mastitis of dairy cows by regulating signal pathway and the amount of PMN.
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