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Cluster Analysis of Differentially Expressed Heat Stress Genes in Rat Jejunal Mucosal

ISSN号：1672-5190
期刊名称：《畜牧与饲料科学》
时间：0
分类：Q78[生物学—分子生物学] O212.4[理学—概率论与数理统计;理学—数学]
作者机构：[1]Department of Animal Science and Technology, Beijing University of Agriculture, Beijing 102206, China, [2]Department of Basic Courses, Beijing University of Agriculture, Beijing 102206, China
相关基金：Supported by General Program of Science and Technology Development Project of Beijing Municipal Education （KM201110020010）; Non-profit Industry Technology Project of the Ministry of Agriculture funded by Funding Program for Academic Human Resources Development in Institutions of Higher Learning Under the Jurisdiction of Beijing Municipality of China [201003060-（9-10）].

作者： Hong ZHAO[1], Huichuan WANG[2], Dan JIA[1], Tingyu YAN[2], Fenghua LIU[1]

关键词：差异表达基因, 聚类分析, 热应激, 空肠粘膜, 大鼠, CYP1A2, SAS软件, 热休克蛋白, Rat, Heat stress, Jejunal mucosal, DNA microarray, Cluster analysis, SAS software

中文摘要：

学习是学习差别的热压力机制的这的目的在老鼠 jejunal mucosal 表示了基因。差别上的样品的可变的簇分析和簇分析在老鼠 jejunal mucosal 表示了热压力基因用 SAS 软件被执行，并且差别的分发的统计在染色体上表示了基因被进行。差别表示了基因被划分成七个范畴，哪个，起来调整的基因包括了三个范畴，下面调整的基因包括了四个范畴。为每个基因范畴的微分表示的分类，功能和原因被分析。大多数起来调整的基因的三个范畴与热吃惊蛋白质有关；并且大多数下面调整的基因的四个范畴与免疫有关，为热压力机制的讨论提供参考。

英文摘要：

[Objective] The aim was to study the heat stress mechanism of differen tially expressed genes in rat jejunal mucosal.[Method] Variable cluster analysis and cluster analysis of samples on the differentially expressed heat stress genes in rat jejunal mucosal were carried out with SAS software,and statistics of distribution of the differentially expressed genes on chromosomes were conducted.[Result] The differentially expressed genes were divided into seven categories,of which,the upregulated genes included three categories （i.e.：Category A：Hspa1a,Hspa1b,Hspb1,Hsph1,Dnaja4,Ahsa2 and P4ha1; Category B：Cyp1a2,Zbtb16,Gucy2g,Fgb,Cyp4a3 and Etv2; and Category C：Cyp1a2,Chac1 and Cyp4b1） and the down-regulated genes included four categories （i.e.：Category D：Tlr2,Noxo1,LOC286989 and Aspg; Category E：RGD1560395,Alb and BQ194726; Category F：Ccl4,Gzmk,Al228153,Anxa10,S100a9 and Ascl5; and Category G：Reg1a and Slc13a1）.The classification,function and reasons of differential expression for each gene category were analyzed.[Conclusion] Most of the three categories of up-regulated genes were related to the heat shock proteins; and most of the four categories of down-regulated genes were related to the immunity,providing reference for discussion of the heat stress mechanism.

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