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“鸡尾酒”疗法治疗儿童原发免疫性血小板减少症临床疗效观察

ISSN号：2095-6606
期刊名称：《现代中医临床》
时间：0
分类：R272[医药卫生—中医儿科学;医药卫生—中医学]
作者机构：[1]北京中医药大学东直门医院,北京100700, [2]首都医科大学附属北京佑安医院, [3]北京市鼓楼中医医院
相关基金：北京中医药大学自主课题（No.2013-ZYLC-009）

作者：余惠平[1], 刘书方[1], 谢欢来[1], 孙蕊芸[2], 郭云山[3], 范小莉[1], 乔俊艳[1]

关键词： “鸡尾酒”疗法, 儿童, 免疫性血小板减少症, 血小板计数, 血小板参数, T淋巴细胞亚群, cocktail therapy , child , immune thrombocytopenia, blood platelet count , clinical effective , platelet parameter, T lymphocyte subsets cell

中文摘要：

目的观察“鸡尾酒”疗法治疗持续、慢性儿童原发免疫性血小板减少症临床疗效。方法选取ITP患儿48例，随机分为2组各24例。治疗组采用“鸡尾酒”治疗（自拟仙芍丹归汤、小剂量甲泼尼龙片、脾氨肽、复方芦丁片、多维片），对照组予归脾汤治疗，疗程均为6个月。比较治疗前后患儿血小板计数，血小板参数，包括平均血小板体积（MPV）、平均血小板分布宽度（PDW）、血小板压积（PCT），T淋巴细胞亚群细胞，包括NK细胞表面标志物（CD3^＋）、辅助性T细胞表面标志物（CD4^＋）、抑制性T细胞表面标志物（CD8^＋），以及CD4^＋／CD8^＋水平的变化。结果治疗总有效率66．67％，高于对照组33．33％，差异有统计学意义（P〈0．05）；在治疗1，3，6个月后治疗组血小板计数均高于对照组，差异有统计学意义（P〈0．05）；治疗1，3个月治疗组PCT高于对照组，差异有统计学意义（P〈0．05）。结论“鸡尾酒”疗法治疗持续、慢性ITP儿童患者有较好的临床疗效。

英文摘要：

Objective To observe the clinical effect of cocktail therapy against persist and chronic im- mune thrombocytopenia （ITP） of children. Methods 48 patients with ITP were randomly divided into treatment group（n = 24）and control group（ n = 24 ）. The treatment group was given cocktail therapy, which is composed by Xianshao Dangui Decoction, small dose of methylprednisolone tablets, spleen amino peptide lyophilized powder, multivitamin tablets, and compound rutin tablets, while the control group re- ceived Guipi Decoction. The treatment lasted 6 months. The changes of platelet count, platelet parameters （MPV,PDW,PCT）, and T lymphocyte subsets cell were compared. Results The total effective rate of the treatment group was 66.67%, which was significantly higher than control group （ 33.33% ）（ P 〈 0. 05 ） ; the platelet counts of the treatment group were higher than that of the control group after 1,3 and 6 months treatment（ P 〈0.05）; the platelet crit（PCT） of the treatment group were higher than control group after 1 and 3 months （P 〈 0.05 ）. There was no significant difference between the two groups of T lymphocyte subsets （P 〉 0.05 ）. Conclusion Cocktail therapy is effective in treating persist and chronic ITP children.

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