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中文摘要：
大肠癌临床常见。有研究表明，大肠癌起源于大肠隐窝干细胞，其基因突变和异常增殖导致大肠癌发生。通过靶向干扰大肠癌干细胞及其异常的调节信号传导通路，可为大肠癌的治疗开辟新的途径。
英文摘要：
Coloreetal cancer is one of the most common malignant tumors in humans. It is demonstrated that the cancer cells originated from intestinal crypt stem cells, which are responsible for gene mutation, abnormal tissue proliferation and then cancer formation. Investigation into the nature of cancer stem cells and their signal transduction pathway may help to develop new therapeutic strategies for colorectal cancer treatment.
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