目的 分析急性冠脉综合征(acute coronary syndrome,ACS)猝死(sudden cardiac death,SCD)患者冠状动脉造影基本影像学特征,探讨其作为ACS猝死危险评估的价值.方法 收集2000-01~2010-12在广西医科大学第一附属医院心研所收治的ACS发生猝死患者共52例,于猝死发作前后1个月内曾行选择性冠状动脉造影.分析冠脉造影病变的特征(病变支数、分布部位、IRA形态改变等因素)与ACS猝死的相关性.结果.冠脉造影,单支、双支和多支病变者分别为15、14和23例,合并左主干病变者7例;IRA狭窄程度为完全闭塞、次全闭塞、严重狭窄、临界狭窄者分别为29、14、6和3例;IRA的冠脉病变呈弥漫性、管状和局限性分别为29、13和10例;IRA分布部位,LAD、RCA、LCX分别为16、30和6例,合并左主干病变者7例,IRA发现血栓14例.冠脉病变支数、IRA长度、合并左主干病变、IRA狭窄程度及IRA分布差异有统计学意义(P值均〈0.05);冠脉病变支数、IRA狭窄程度、IRA分布对冠心病猝死发生影响具有统计学意义(P〈0.05).结论.ACS患者猝死多存在多支和严重的冠脉病变基础,IRA病变狭窄程度较重,需要紧急血运重建.
Objective To assess the angiographic characteristies of coronary lesions in patients with acute coronary syndrome who experienced sudden heart arrest and evaluate the significance of coronary angiography on risk stratification of ACS. Methods The data of 52 consecutive patients with acute coroary syndrome experienced sudden heart arrest underwent coronary angiography a month within the cardiac arrest attack were collected and the severity of stenosis , the location and the length of the coronory lesions were evaluated. Results Single factor test shows that location, the severity of stenosis, the length of lesion of IRA and the number of culprit vessel enter the formula ( P 〈 0.05 ), and then location ,the severity of stenosis of IRA and the number of culprit vessel are associated with a increased risk of SCD by multi - faetor logistic regression analysis. Conclusion Our study shows that patients with ACS experienced sudden coronals, death usually suffer multi -vessel lesions with more severe stenosis of IRA, Coronary angiography may serve as a reference on risk stratification for sudden coronary death.