中文摘要：

目的：探讨血清学筛查唐氏综合征高风险与不良妊娠结局发生的关系。方法：以血清学筛查且唐氏综合征风险值≥1/270的孕妇列为高危组,唐氏综合征风险值〈1/270的孕妇列为低危组,对高危组、低危组的胎儿染色体病、系统超声检查结果、妊娠并发症、新生儿情况等进行分析。结果：807例高危组患者21-三体、超声结构畸形、自然流产、死胎、胎盘早剥、新生儿窒息发生率分别为1.36%（11/807）、4.96%（40/807）、4.09%（33/807）、2.11%（17/807）、1.12%（9/807）、1.36%（11/807）,均高于低危组（n=1 614）的0.06%（1/1 614）、1.80%（29/1 614）、0.12%（2/1 614）、0.31%（5/1 614）、0.31%（5/1 614）、0.25%（4/1 614）,差异均有统计学意义（P〈0.05）。结论：血清学筛查唐氏综合征高风险病例,不良妊娠结局发生率高。

英文摘要：

Objective： To investigate the relationship between high-risk serum screening for Down＇s syndrome（DS） and the incidence of adverse pregnancy outcomes. Methods： Pregnant women who underwent serum screening for DS were investigated. Eight hundred and seven cases whose value of serum screening for DS was ≥ 1/270 were identified as high-risk group, 1 614 cases whose value of serum screening for DS was 〈 1/270 were identified as low-risk group. Fetal chromosomal diseases, genetic sonography, pregnancy complications, and neonatal outcomes of pregnant women were compared between high-risk group and low-risk group. Results： In high-risk group, the incidence of DS, sonographically structural abnormality, abortion, fetal death, placental abruption and neonatal asphyxia were 1.36%（11/807）, 4.96%（40/807）, 4.09%（33/807）, 2.11%（17/807）, 1.12%（9/807） and 1.36%（11/807）, respectively, which were all higher than those in low-risk group,they were 0.06%（1/1 614）, 1.80%（29/1 614）, 0.12%（2/1 614）, 0.31%（5/1 614）, 0.31%（5/1 614） and 0.25%（4/1 614）, respectively（P〈0.05）. Conclusion： Among the cases with high-risk serum screening for DS, the incidence of adverse pregnancy outcomes was high.