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中文摘要：
目的探讨卵泡刺激素受体（FSHR）基因多态性与控制性超排卵结局的关系。方法收集生殖中心的病例103例,抽取外周血提取DNA,用PCR限制酶切法,分析FSHR 680位点的单核苷酸多态性,并分为A组（N/N）、B组（N/S）和C组（S/S）3组,比较各组间的促排卵结局。结果促排卵过程中,低反应、中反应和高反应的发生率3组类似;3组间基础FSH值、Gn用量以及获卵率、受精率、卵裂率、优质胚胎率及妊娠率差异均无统计学意义。C组的妊娠率（54.6%）高于B组（35.7%）和A组（51.3%）。结论 FSHR 680位点的多态性可能与卵巢的反应性无关,S/S基因型可能与胚胎的质量有关。
英文摘要：
Objective To explore the relationship between follicle-stimulating hormone receptor（FSHR）polymorphism and outcome of controlled ovarian hyper-stimulating.Methods Totally 103 women who underwent vitro fertilization and embryo transfer（IVF-ET）cycle were analyzed,drawn the blood,extracted the genomic DNA,FSHR gene intra-cytoplasmic sperm injection SNPs were analyzed by PCR and RFLP（polymerase chain reaction-restriction fragment length polymorphism）.The FSHR gene polymorphisms at position 680 were divided into 3gene-type groups,A（N/N）,B（N/S）and C（S/S）and IVF-ET outcomes were analyzed.Results In the process of controlled ovarian hyper-stimulation,the rates of low,normal and high response were similar in three groups and there were no significant differences in the rates of oocytes retrieved,fertilization,cleavage and clinical pregnancy.The rate of clinical pregnancy in group C（54.6%）was higher than that of group A（51.3%）and group B（35.7%）.Conclusion The FSHR Asn680 Ser may be no association with ovarian response.Gene-type S/S may be related to the quality of embryo.
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