中文摘要：

目的 探讨不孕不育人群中染色体多态性与辅助生殖助孕结局的关系.方法 收集福建省妇幼保健院生殖中心共1 300对夫妇病例,染色体多态性阳性者96对（7.4％）;以取卵的79个周期纳入研究对象,随机选取染色体正常的140个周期为对照.比较染色体多态性携带女方（A组）、男方（B组）和染色体正常者（C组）的生殖助孕结局.结果 染色体多态性阳性者96对中,染色体多态性女方携带47人、男方49人.多态性染色体检出率：D/G组染色体2.1％;Y染色体0.3％;1、9、16号染色体1.5％.3组间年龄、基础卵泡生成激素、黄体生成激素、催乳素、雌二醇、睾酮及促性腺激素的用量和使用天数差异均无统计学意义;获卵数、受精数、卵裂数、优质胚胎数、囊胚形成数、优质囊胚率、妊娠率类似;IVF与ICSI受精率差异无统计学意义;但流产率A组最高.结论 胚胎早期流产可能与女性染色体多态性有关,但对辅助生殖助孕结局均无影响.

英文摘要：

Objective To explore the relationship between chromosomal polymorphism of infertile couples and assisted reproductive outcome. Methods Totally 1300 couples were collected from the reproductive center of Fujian Provincial Maternity and Children＇s Hospital. Totally 96 couples with chromosomal polymorphism and the positive rate was 7.4%. 79 cycles in 96 couples were recruited and 140 cycles with normal karyotype were selected randomly as control group. Reproductive outcomes of group A, B and C were compared （female with chromosomal polymorphism as group A;male with chromosomal polymorphism as group B, normal karyotype as group C）. Results In 96 couples with chromosomal polymorphism, 47 for group A and 49 for group B. The detect rates： D/G group was 2.1% ,Y was 0.3%, 1, 9 and 16 was 1.5%. There were no significant different for mean age, fertilization, cleavage, high quality embryo, blastocyst formation rate, high quality blastocyst rate and pregnancy rate in three groups. There were no significant different for IVF and ICSI fertilization rates. But early miscarriage rate was highest in group A. Conclusion Early miscarriage may be related to female chromosomal polymorphism, but no effect on the outcomes of assisted reproduction.