中文摘要：

目的：预防性宫体注射卡前列素氨丁三醇在具有产后出血高危因素孕妇剖宫产术中的应用效果观察。方法选取2013年1月-2014年5月本院产科待产并且合并有产后出血高危因素的116例孕妇随机分两为组，对照组（n=59）给予产后出血的常规防治措施，观察组（n=57）加用卡前列素氨丁三醇宫颈或宫体注射，对两组产妇产后出血发生率、产后出血量及药物不良反应发生情况进行综合比较。结果观察组产后出血率为12.28%，对照组为27.12%，两组产妇产后出血发生率比较，差异有统计学意义（P〈0.05）；观察组产妇产后2、24 h的平均出血量分别为（209.5±57.0）、（305.8±70.5）ml，对照组分别为（314.2±69.1）、（370.1±76.4）ml，观察组均明显少于对照组（P〈0.01）；观察组出现恶心、呕吐等胃肠道反应7例（12.28%），寒战1例（1.75%），发热1例（1.75%），面部潮红1例（1.75%），上述不良反应均自行缓解，对照组患者无明显药物不良反应情况发生，两组无一例患者因严重药物不良反应而停止治疗。结论针对有产后出血高危因素的临床孕产妇，预防性宫颈或宫体注射卡前列素氨丁三醇能明显降低产后出血率及出血量，安全性高，值得临床推广应用。

英文摘要：

Objective To observe the application effect of preventive injection of romethamine into the uterine body of the pregnant women with high risk factors of postpartum hemorrhage in cesarean section. Methods 116 cases of preg-nant women with high risk factors of postpartum hemorrhage in cesarean section to produce in our hospital from Jan-uary 2013 to May 2014 were selected and randomly divided into two groups.The pregnant women （n=59） in control group were given the conventional measures and treatment of postpartum hemorrhage while the pregnant women （n=57） in observation group were treated with uterine body injection of romethamine based on the treatment of control group. The rate of hemorrhage,amount of postpartum hemorrhage and the incidence of adverse drug reactions of patients be-tween two groups were comprehensively compared. Results The rate of postpartum hemorrhage in observation group ac-counted for 12.28% while that in control group accounted for 27.12%.The incidence of postpartum hemorrhage of two groups had significant difference （P〈0.05）;The average amount of blood loss of the patients 2,24 h in observation group were[（209.5±57.0）,（305.8±70.5） ml] while that in control group were（314.2±69.1） ml and （370.1±76.4） ml,The average amount of blood loss of the patients in observation group was significantly less than that in control group（P〈0.01）.7 cas-es（12.28%） in observation group had nausea,vomiting and other gastrointestinal reactions,1 cases had chills （1.75%）,1 cases had a fever （1.75%） and 1 cases had facial flushing （1.75%）.The adverse reactions above could be relieved by themselves.There was no obvious adverse drug reaction in control group.There were not any patient who stopped receiv-ing the treatment between two groups because of severe adverse reaction. Conclusion For the pregnant women with high risk factors of postpartum hemorrhage,the preventive uterine body injection of romethamine can significantly re-duce the rate of postpartum hemorrh