中文摘要：

目的：探讨血清学筛查在高龄孕妇产前诊断中的应用价值。方法回顾性分析2012年1月1日-2012年10月31日行胎儿染色体核型分析的高龄孕妇314例，按预产期年龄分为35～39岁组和≥40岁组；按血清学筛查情况分为血清学筛查低危组、血清学筛查高危组和未做血清学筛查组，分析各组胎儿染色体异常率。结果胎儿染色体异常率4．14％（13/314）。≥40岁组胎儿染色体异常率13．21％（7/53），高于35～39岁组2．30％（6/261）（ P＝0．001）。血清学筛查高危组胎儿染色体异常率7．69％（7/91），高于血清学筛查低危组0（0/64）（ P＝0．022）。结论对高龄孕妇进行血清学筛查，有助于减少介入性产前诊断率。

英文摘要：

Objective To investigate the incidence of chromosome abnormalities in advanced maternalage（AMA） ,and to investigate the value of prenatal screening in AMA . Methods Retrospective analysis of 314 cases of AMA which had invasive prenatal diagnosis .314 cases of AMA were divided into two groups according to expected date of childbirth age ：35~39 years old and older than 40 years old . And they were also divided into three groups according to serum screening ：low-risk serum screening group ,high-risk serum screening and without serum screeningand ,to analyze the percentage of fetal chro-mosome abnormalities in these groups . Results The percentage of fetal chromosomal abnormalities of 314 AMA was 4 .14% （13/314） . The percentage of fetal chromosomal abnormalities in AMA whose ma-ternal age older than 40 years old was 13 .21% （7/53） ,which was higher than that in AMA whose mater-nal age 35~39 years old 2 .30% （6/261） （P=0 .001） . In high-risk serum screening group ,the percent-age of fetal chromosome abnormalities was 7 .69% （7/91） ,which was higher than that in low-risk serum screening group 0 （0/64） （P=0 .022） . Conclusions Maternal prenatal screening tests could be applied in AMA .