中文摘要：

目的 探讨孕妇发砷含量与胎儿先天性心脏病（CHD）的关系.方法 采用病例对照研究,收集福建省妇幼保健院相关病例61例,对照组61例按年龄及孕周1∶1配对.检测分析研究对象的发砷含量,进行问卷调查和分析.结果 发砷含量（中位数）病例组孕妇（0.098 μg/g）高于对照组（0.066μg/g）;病例组胎儿心脏畸形简单型孕妇发砷含量（0.0892 μg/g）低于复杂型（0.1227μg/g）;复杂型中合并2种、3种和4种心脏畸形孕妇的发砷含量分别为0.1177、0.1212和0.1429 μg/g;多因素分析发现,孕妇发砷含量、孕妇为家庭主厨、孕期接触化学制剂是CHD的危险因素;孕前食用乳制品为CHD的保护因素.结论 胎儿CHD发生与孕妇发砷含量水平有关,发砷含量越高胎儿CHD风险越大.在孕前保健时对发砷含量较高的妇女进行干预,有助于降低胎儿CHD的发病风险.

英文摘要：

Objective To investigate the relationship between arsenic content of pregnant woman hair and fetal congenital heart disease. Methods By using 1 ： 1 matched case-control study, totally 61 cases and 61 control were collected in Fujian Provincial Maternity and Children＇s Hospital,and hair arsenic contents of pregnant women were detected and questionnaire studies were conducted. Results The hair arsenic contents （median） in case group（0.098 μg/g）was higher than that of control group （0.066 μg/g）.In case group,the hair arsenic contents in simple CHD cases （0.089 μg/g）was lower than that of the complex CHD cases （0.1227 μg/g）. And the arsenic contents of the cases with 2,3 and 4 kinds of CHD were 0. l177μg/g, 0.1212μg/g and 0. 1429μg/g respectively. Multivariate analysis showed that hair arsenic content,family chief and chemical exposure for the pregnant woman were the risk factors for CHD,and taking dairy products before pregnancy was a protective factor. Conclusion The fetal CHD is significantly related to the hair arsenic content of pregnant woman. The more hair arsenic content of pregnant woman, the more risk for fetal CHD. The early intervention for woman with higher arsenic level in pregnancy may be helpful to reduce the risk of the fetal CHD.