中文摘要：

目的探讨冠脉介入治疗对不稳定型心绞痛冠心病患者血清炎性因子水平的影响。方法选取2014年6月~2015年6月于我院行冠脉介入治疗的不稳定型心绞痛冠心病患者38例,作为研究对象。所有患者均经造影及影像学、心电图检查确诊为不稳定型心绞痛冠心病,满足冠脉介入治疗手术指征,采集所有患者冠脉介入前6 h、术后6 h、术后24 h时患者外周血标本,检测患者血清炎性因子水平,主要观察IL-6、IL-10、hs-CRP及MMP-9水平。结果所有患者术后6 h IL-6、IL-10、hs-CRP及MMP-9水平明显较术前6 h升高,差异具有统计学意义（P〈0.05）;术后24 h IL-6、IL-10、hs-CRP及MMP-9水平较术后6 h明显降低,但仍明显高于术前6 h,差异有统计学意义（P〈0.05）。结论冠脉介入治疗可导致不稳定型心绞痛冠心病患者血清炎性因子水平的升高,这主要与手术医源性创伤及患者心肌细胞损伤有关,临床应重视冠脉介入术后炎性因子水平的升高。

英文摘要：

Objective To discuss the influence of coronary artery intervention on serum inflammatory factor levels in patients with unstable angina pectoris coronary heart disease. Methods A total of 38 patients with unstable angina pectoris coronary heart disease who were given coronary artery intervention in our hospital from June 2014 to June 2015 were selected. All patients were confirmed as unstable angina pectoris coronary heart disease with indications of intervention surgery by radiography, iconography, and ECG. Peripheral blood samples of all patients were collected at 6h before intervention, and 6 h and 24 h after intervention, and the levels of serum inflammatory factors were detected,espe cially the levels of IL-6, IL-10, hs-CRP, and MMP-9. Results The levels of IL-6, IL-10, hs-CRP, and MMP-9 were significantly higher at 6 h after intervention than those at 6 h before operation in all patients（P〈0.05）. The levels of IL-6, IL-10, hs-CRP, and MMP-9 were significantly lower at 24 h after intervention than those at 6 h after intervention, but still evidently higher than those at 6 h before operation in all patients（P〈0.05）. Conclusion Coronary artery intervention can lead to enhancement of serum inflammatory factor levels in patients with unstable angina pectoris coronary heart disease, which is mainly related to iatrogenic trauma in surgery and myocardial cell injury of patients, and should be paid attention in clinical practice.