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中文摘要：
目的：选择短链氯化石蜡含量不同的两种氯化石蜡产品（CPsⅠ，38．22％和CPsⅡ，0．08％）作为模式化合物，比较它们经口连续灌胃暴露14d后对SD雄性大鼠的影响，借以探讨短链氯化石蜡是否存在特殊的毒性效应。方法：CPsⅠ和CPsⅡ的暴露浓度分别为lO、50、100mg／kg（CPsI）和100mg／kg（CPsⅡ）。结果：两种氯化石蜡产品暴露后，对大鼠的摄食、体重无明显影响。CPsⅠ和CPsⅡ急性暴露，均可造成大鼠的肝脏中肝细胞肿胀、水样变性及胞质疏散；肾脏中肾小管肿胀，肾小球萎缩、肾小球玻璃样变；肺部中肺泡隔增厚，炎症细胞浸润等明显的组织病理学改变。结论：氯化石蜡急性暴露对SD雄性大鼠所产生的毒性效应，与样品中短链氯化石蜡的含量并无显著性关联。
英文摘要：
Objective： Chooses two chlorinated paraffins products which contain different con- tent of short chain chlorinated paraffins （SCCP） as model compound （CPs Ⅰ , 38.22% and CPs Ⅱ , 0.08%）, compares their influence on SD male rats after continuously 14 days being exposed through oral intragastric administration, according to that, to explore whether there is special toxicity of SC- CP or not. Methods： The exposing concentration are 10, 50,100（CPs Ⅰ ）, 100（CPs Ⅱ ） mg/kg, re- spectively. Results： After being exposed under two chlorinated paraffins, there is no obvious influ- ence on food intaking and weight. CPs Ⅰ and CPs Ⅱ acute exposing, can cause hepatocyte swelling, hydropic degeneration, cytoplast loosen; and renal tubule swelling, glomerulus atrophy, glomerulus hyalinosis; and alveolar septum incrassation, inflammatory cell infiltration; and so on histopatholo- gy changes. Conclusion： Acute chlorinated paraffines exposing has toxicity to SD male rats, the ef- fect has no significant relationship with the content of SCCP.
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