中文摘要：

目的观察滋膊降糖方对初发2型糖尿病（T2DM）患者胰岛B细胞功能的影响。方法将120例初发T2DM患者随机分为两组，治疗组60例予以中药滋脾降糖方干预，1剂／d，分2次口服；对照组60例予以吡格列酮15mg／次，1次／d；两组疗程均为8w。观察治疗前后两组血糖、胰岛索、李氏B细胞功能指数（MBCI）、胰岛素敏感指数（ISI）的变化。结果治疗后两组患者空腹血糖（FPG）、餐后1h血糖（1hPG）、餐后2h血糖（2hPG）均较治疗前显著下降，ISI及MBCI显著升高（P〈0．01）；治疗组1hPG、2hPG及MBCI均较对照组改善更明显（P〈0．05或P％0．01）。结论对于初发T2DM患者，滋膊降糖方和吡格列酮均有改善胰岛口细胞功能、增加胰岛素敏感性及控制血糖的作用，但滋膊降糖方改善胰岛8细胞功能的效果优于吡格列酮。

英文摘要：

Objective To observe the influence of Zicuijiangtang Prescription on the function of pancreatic β cells in patients with initially-occurred type 2 diabetes mellitus （T2DM）. Methods One hundred and twenty patients with initially-occurred T2DM were randomly divided into treatment group （n = 60）, which was orally intervened by Zicuijiangtang Prescription one dosage daily in twice doses,and control group （n= 60）, that was given ploglitazone 15 mg each time,once daily,8 weeks as a course of treatment. The changes of blood glucose,insulin,Lee ＇s modified β-cetl function indexes （MBCI） and insulin sensitivity indexes （ISI） in two groups were observed. Results After treatment,fasting plasma glucose （FPG）,plasma glucose 1 h our after meal （1 h PG） and plasma glucose 2 hour after meal（2 h PG） of two groups decreased significantly than treatment before, whereas MBCI and ISI increased evidently （P〈0.01）; improved 1 h PG,2 h PG and MBCI in treatment group were more remarkable than that in control group （P〈0.05 or P〈0.01）. Conclusion For patients with initially-occurred T2DM,Zicuijiangtang Prescription is better than ploglitazone in improving insulin 13-cell function, increasing insulin sensitivity and controlling blood glucose.