中文摘要：

目的：探讨艾灸启动内源性保护信息对胃黏膜的保护效应与腓总神经通路的关系。方法：将48只SpragueDawley（SD）大鼠随机分为正常组（A组）,模型组（B组）,艾灸模型组（C组）和艾灸模型手术组（D组）,每组12只。除A组外,其余各组用无水乙醇、阿司匹林灌胃制备胃黏膜损伤模型。B组不予治疗干预;C组予艾灸足三里治疗,每日2次,连续治疗3 d;D组进行腓总神经切断术后制备胃黏膜损伤模型,予以艾灸足三里治疗。干预3 d后观察各组胃黏膜损伤指数（UI）,并进行胃黏膜相关修复细胞因子肿瘤坏死因子-α（TNF-α）、白介素-4（IL-4）和热休克蛋白70（HSP70）检测。结果：与A组相比,B组病理及UI改变较差（P=0.000）;血清与组织中TNF-α改变明显（P=0.000,P=0.002）;血清与组织中IL-4改善明显（P=0.000,P=0.000）。与B组相比,C组和D组TNF-α与IL-4改善明显（TNF-α：P=0.003,P=0.016;IL-4：P=0.000,P=0.002）。与C组比较,B组和D组UI改变效果较差（均P=0.000）;血清中TNF-α与IL-4下降明显（TNF-α：P=0.000,P=0.025;IL-4：P=0.000,P=0.034）;组织中HSP70值下降明显（P=0.000,P=0.033）。结论：足三里穴可通过腓总神经途径传递信息,调节胃黏膜保护因子的释放,并上调细胞修复相关蛋白表达,从而达到修复胃黏膜的效应。

英文摘要：

Objective： To investigate the protective effect of moxibustion in initiating the endogenous protection information on gastric mucosa, and its relationship with the pathway of common peroneal nerve. Methods： Forty-eight Sprague-Dawley（SD） rats were randomly divided into a normal group（group A）, a model group（group B）, a moxibustion model group（group C） and a moxibustion model plus surgery group（group D）, 12 in each group. Except for group A, rats in the other groups were treated with dehydrated ethanol and aspirin to prepare gastric mucosal damage model. The rats in group B were not treated with any interventions; rats in group C received moxibustion at Zusanli（ST 36）, twice a day for continuous 3 d. The rats in group D were subjected to preparing the gastric mucosal damage model after the common peroneal nerve transection, followed by moxibustion at Zusanli（ST 36）. After a 3-day intervention, ulcer index（UI） in each group was observed, and the levels of gastric mucosa-related repair cytokines of tumor necrosis factor-α（TNF-α）, interleukin-4（IL-4） and heat shock protein 70（HSP70） were detected. Results： Compared with group A, the pathological changes and UI of group B were worse（P=0.000）, but TNF-α in serum and tissue was changed significantly（P=0.000, P=0.002）, IL-4 in serum and tissue was improved significantly（P=0.000, P=0.000）. Compared with group B, TNF-α and IL-4 in group C and group D were significantly improved（TNF-α： P=0.003, P=0.016; IL-4： P=0.000, P=0.002）. Compared with group C, the changes of UI in group B and group D were poor（both P=0.000）; the levels of TNF-α and IL-4 in serum were significantly decreased（TNF-α： P=0.000, P=0.025; IL-4： P=0.000, P=0.034）; and tissue HSP70 levels were decreased significantly（P=0.000, P=0.033）. Conclusion： Zusanli（ST 36） can transmit information through the pathway of common peroneal nerve, regulate the release of gastric mucosal protective factors, and up-regulate the e