中文摘要：

目的观察隔药饼灸对功能性消化不良（Functional Dyspepsia,FD）肝郁脾虚型模型大鼠血清白介素-6（interleukin-6,IL-6）、白介素-1β（interleukin-1β,IL-1β）及肿瘤坏死因子-α（tumor necrosis factor-α,TNF-α）的影响,探讨隔药饼灸治疗FD的另一可能作用机制。方法将50只SD大鼠根据随机数字表法随机分为5组,空白组、模型组、隔药饼灸组、艾炷灸组、逍遥散组每组各10只,空白组正常饲养,其余4组均采用复合病因法（慢性束缚应激＋过度疲劳＋饮食失节＋夹尾＋摇晃）进行造模,造模21 d后按被试因素分组治疗14d,采用酶联免疫吸附法（ELISA法）检测大鼠血清中IL-6、IL-1β及TN F-α的含量。结果与空白组比较,模型大鼠血清IL-6、IL-1β及TN F-α含量均增加,差异有统计学意义（P〈0.01）;与模型组比较,隔药饼灸组、艾炷灸组、逍遥散组大鼠血清IL-6、IL-1β及TN F-α均下降（P〈0.01）,且隔药饼灸组效果优于艾炷灸组、逍遥散组,差异具有统计学意义（P〈0.01）;与艾炷灸组比较,隔药饼灸组、逍遥散组大鼠血清IL-6、IL-1β及TN F-α均下降,差异具有统计学意义（P〈0.01）。结论隔药饼灸可能是通过下调促炎因子,纠正IL-6、IL-1β及TN F-α的失衡,促进胃肠动力恢复,从而达到治疗该病的目的。

英文摘要：

Objective To observe the effect of cake-separated moxibustion on interleukin-6, interleukin-1β and tumor necrosis factor-αof functional dyspepsia（FD） rats, and to explore the herbal cake-separated-moxibustion another possible mechanism for treatment of FD. Methods According to random number table method, 50 SD rats were randomly divided into blank group, model group, herbal cake-separated moxibustion group, moxa-cone moxibustion group and Xiaoyao powder group, and each group had 10 rats. The blank group received normal feeding, the the rest of the four groups underwent modeling by applying chronic restraint stress, excessive fatigue, irregularfood, clip tail, shaking for 21 consecutive days. Then each group underwent treatment respectively for 14 days. At the end of the experiment, the contents of IL-6, IL-1β and TNF-α in rats serum were detected by enzyme linked immunosorbent assay method. Results As compared with blank group, the serum levels of IL-6, IL-1β and TNF-α in the model rats were increased, there had significant differences（P〈0.01）. Comparing with the model group, the serum levels of IL-6, IL-1β and TNF-α were decreased in herbal cake-separated moxibustion group, moxa-cone moxibustion group and Xiaoyao powder group（P〈0.01）, and herbal cakeseparated moxibustion group was better than moxa-cone moxibustion group and Xiaoyao powder group, and there had significant differences（P〈0.01）. Comparing with tomoxa-cone moxibustion group, the serum levels of IL-6, IL-1β and TNF-α were decreased in herbal cake-separated moxibustion group and Xiaoyao powder group（P〈0.01）, and there were significant differences（P〈0.01）.Conclusion The cake-separated moxibustion may be via to down regulation of proinflammatory factors and correct the imbalance of IL-6, IL-1β and TNF-α, promote the recovery of gastrointestinal motility, so as to achieve the purpose of treatment of the disease.