欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
目的：研究神经型钙黏蛋白（N-cadherin）在肝门部胆管癌组织中的表达及临床意义。方法免疫组化检测26例肝门部胆管癌与癌旁及5例正常胆管组织中N-cadherin表达差异。Western blot对比N-cadherin在肝门部胆管癌组织中与癌旁中差异。结果免疫组化示26例肝门部胆管癌癌组织中有14例N-cadherin表达阳性，癌旁组织中6例阳性（P〈0.05）。正常胆管阳性表达0例。N-cadherin在低分化癌组阳性表达率高于中、高分化癌组。Western blot示N-cadherin在肝门部胆管癌组织中的表达高于癌旁组织（0.88±0.12 vs 0.43±0.09,P〈0.05）。结论 N-cadherin可能参与肝门部胆管癌的发生发展。
英文摘要：
Objective To explore the expression and the clinical significance of neural cadherin （N-cadherin） in perihilar cholangiocarcinoma. Methods The expression of N-cadherin was detected by immunohistochemical method in 26 patients with perihilar cholangiocarcinoma and 5 samples of normal bile duct tissues. The expression of N-cadherin was also compared by Western blotting assay between perihilar cholangiocarcinoma and paraneoplastic tissues. Results The im-munohistochemical results showed that positive expression of N-cadherin was observed in 14 of 26 patients with perihilar cholangiocarcinoma and in 6 of 26 paraneoplastic samples （53.84%vs 23.08%, P〈0.05）. There was 0 N-cadherin expres-sion in normal bile duct tissues. The positive rate of N-cadherin expression was higher in low differentiated group than that in middle and well differentiated groups. The result of Western blotting assay showed that N-cadherin expression was signifi-cantly higher in perihilar cholangiocarcinoma than that in the paraneoplastic tissues （0.88 ± 0.12 vs 0.43 ± 0.09, P 〈 0.05）. Conclusion N-cadherin may be involved in the occurrence and development of perihilar cholangiocarcinoma.
同期刊论文项目
同项目期刊论文
期刊信息
位置：