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中文摘要：
目的 探讨自体造血干细胞移植（auto-HSCT）治疗淋巴瘤患者移植相关并发症的预防及处理,同时比较不同预处理方案的疗效及不良反应。方法 选择2006年6月至2015年6月于该院血液科行auto-HSCT治疗的87例淋巴瘤患者作为研究对象。按照移植预处理方案不同,将其分为BEAM方案预处理组（41例）和BEAC方案预处理组（46例）。结果 两组患者的性别、年龄、淋巴瘤分期、中位随访时间及病理类型等差异均无统计学意义（P〉0.05）。87例患者均成功获得造血重建,BEAC组与BEAM组比较,中性粒细胞植入时间差异无统计学意义[11（8-15）d vs.12（8-16）d,P=0.589 7],而血小板植入时间BEAC组优于BEAM组[13（10-17）d vs.15（11-19）d,P=0.015 3]。两组患者预处理不良反应相似,无肝静脉闭塞病及移植相关死亡发生。中位随访61（3-120）个月,预期3年生存率分别为83.23%和86.56%（P=0.639 3）,5年生存率分别为69.47%和77.60%（P=0.479 9）。结论 BEAM和BEAC预处理方案auto-HSCT都是治疗淋巴瘤安全、有效的方法,其远期疗效尚待长期随访观察。
英文摘要：
Objective To investigate the prevention and treatment of transplant-related complications,and compare the effi- cacy and adverse effects of different conditioning regiment after autologous hematopoietic stem cell transplantation （auto-HSCT） for lymphoma patients. Methods Between June 2006 and June 2015,87 consecutive patients with lymphoma treated with auto- HSCT were received in hematology department of our Hospital. According to conditioning regiment,the patients were divided into BEAM conditioning regiment group （n= 41） and BEAC conditioning regiment group （n= 46）. Results Between the two groups, the distribution of gender,age, lymphoma stage, the median follow-up time and the pathological type were not significantly different （P〉0.05）. All patients achieved hematopoietic reconstruction successfully. The median time to neutrophil engraftment was 11 days （range 8-15 days） in BEAC group and 12 days （range 8-16 days） in BEAM group （P= 0. 589 7）. The median time of platelet engraftment in BEAC group （ 13 days, range 10- 17 days） was superior than that in BEAM group （ 15 days, range 11 - 19 days）, with significant difference（P=0. 015 3）. The adverse effects of conditioning regiment in both groups were similar, there was no he- patic vein occlusion disease and transplant-related deaths occurred. The 3-year survival rate for the BEAC and BEAM groups was 83.23% and 86. 56% respectively（P= 0. 639 3）. The 5-year survival rate for the BEAC and BEAM groups was 69.47% and 77.60% respectively （P= 0. 479 9）. Conclusion The results show that BEAM and BEAC conditioning regiment are safe and effec- tive for lymphoma with auto-HSCT,however,the long-term efficacy will wait for the long-term follow-up.
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