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食管鳞状细胞癌组织中Galectin-9和MMP-2蛋白的表达及与预后的关系

ISSN号：1671-6825
期刊名称：《郑州大学学报：医学版》
时间：0
分类：R735.1[医药卫生—肿瘤;医药卫生—临床医学]
作者机构：[1]郑州大学第二附属医院消化内科,郑州450014, [2]郑州大学第二附属医院消化研究所,郑州450014
相关基金：河南省医学科技攻关计划普通项目200903060

作者：郭素平[1], 马军[2], 唐芙爱[1], 鲁迪[1], 段芳龄[2], 郭琦[1]

关键词：食管肿瘤, 鳞状细胞癌, 组织芯片, 半乳糖凝集素-9, 基质金属蛋白酶-2, 预后, esophagus neoplasm, squamous cell carcinoma, tissue microarray, Galectin-9, MMP-2, prognosis

中文摘要：

目的：探讨食管鳞状细胞癌（简称食管鳞癌）组织中Galectin-9和MMP-2蛋白的表达及与预后的关系。方法：制备组织芯片,应用免疫组化SP法检测63例食管鳞癌及其癌旁正常食管黏膜组织中Galectin-9和MMP-2蛋白的表达,分析2种蛋白的表达与临床病理指标和预后的关系。结果：食管鳞癌组织中Galectin-9蛋白的阳性表达率为62.5%,低于癌旁正常食管黏膜组织的89.3%（χ2=11.529,P〈0.001）,其表达与肿瘤的分化程度有关（P=0.001）,且阳性表达者生存期更长（P=0.013）。食管鳞癌组织中MMP-2蛋白的阳性表达率为67.9%,高于癌旁正常食管黏膜组织的35.7%（χ2=9.633,P=0.001）,其表达与肿瘤浸润深度、TNM分期、淋巴结转移有关（P均〈0.05）,且阳性表达者生存期较短（P=0.036）。结论：食管鳞癌组织中Galectin-9低表达,MMP-2高表达;检测二者可用于判断食管鳞癌预后。

英文摘要：

Aim：To explore the expressions of Galectin-9 and MMP-2 proteins,and the relationship between their expressions and prognosis of the patients with esophagus squamous cell carcinoma（ESCC）.Methods：The expressions of Galectin-9 and MMP-2 proteins in 63 cases of ESCC and adjacent non-tumor tissue were detected using tissue microarray and immunohistochemical technique.The association of Galectin-9 and MMP-2 protein expressions with clinicopathologic data and survival were analyzed.Results：The positive expression rate of Galectin-9 protein in adjacent non-tumor tissue and ESCC tissue were 89.3% and 62.5%,and there was significant difference（χ2=11.529,P0.001）.In ESCC,its expression was related with tumor differentiation（P=0.001）.The patients with Galectin-9 positive expression had a longer survival period（P=0.013）.The positive rate of MMP-2 protein in adjacent non-tumor tissue and ESCC tissue were 35.7% and 67.9%,and there was significant difference（χ2=9.633,P=0.001）.In ESCC,the expression of MMP-2 was related with tumor invasion,lymph node metastasis,and clinical stage,and patients with MMP-2 positive expression showed a shorter survival period（P=0.036）.Conclusion：In ESCC,the Galectin-9 protein is down-regulated and MMP-2 is up-regulated.Galectin-9 and MMP-2 could be markers for prognostic diagnosis of ESCC.

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