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中文摘要：
目的探讨中国黑龙江地区汉族人群中5-HT6基因多态性与阿尔茨海默病（AD）的相关性。方法应用限制性片段长度多态性（RFLP）技术和聚合酶链反应（PCR），在95例正常对照人群和105例阿尔茨海默病患者中观察5-HT6 基因多态性的分布，并探讨它们与阿尔获海默病之间的关系。结果在受试人群进行载脂蛋白E（ApoE）基因分型后，非ApoEε4型与ApoEε4型人群中AD与5-HT6受体基因各基因型或等位基因均无关联（P〉0．05），AD组5-HR受体基因和C/ 基因型明显高于对照组，两组间差异有统计学意义（P〈0．05）。结论中国黑龙江地区汉族人群中5-HT。受体基因多态性与非ApoEε4型阿尔茨海默病相关联。
英文摘要：
Objective To explore the correlation of 5-HT6 gene polymorphism and Alzheimer disease （AD） in Han population of Heilongjiang district of China. Methods Applying the restriction fragment length polymorphism （RFLP） technique and the polymerase chain reaction （PCR）, the distribution of 5-HT6 gene polymorphism was observed in 95 cases of normal controls and 105 cases of patients with Alzheimer disease, and it explored the relationship between them and Alzheimer disease. Results After studied subjects being classified by ApoE gene, there was no correlation （P 〉 0.05） between AD and 5-HT6 receptor gene of genotypes or allele in type of non-ApoEε4 type and ApoEε4 crowd, and group AD of 5-HT6 receptor gene and C/T genotype was significantly higher than the control group, the differ- ences between the two groups were statistically significant （P 〈 0.05）. Conclusion 5-HT6 gene polymorphism are rele- vant to the Alzheimer disease of non-ApoEε4 type in Han population of Heilongjiang district of China.
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