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中文摘要：
目的探讨鹿茸多肽对皮肤创面愈合的影响。方法将48只大鼠随机分成对照组和实验1组、实验2组、实验3组,每组12只。以大鼠背部脊柱为中心设计5 cm×5 cm创面,实验1组单纯肌肉注射鹿茸多肽,实验2组单纯创口外部用鹿茸多肽,实验3组则肌注与外部混合应用,均每日给药1次,分别于24,6,,8,10,121,4 d观察创面的愈合情况;于第10天测量创面大小,计算愈合面积及愈合速度;计数单位质量组织细菌数;测定肉芽组织羟脯氨酸含量。结果创面愈合面积、愈合速度和肉芽组织羟脯氨酸含量实验3组优于其他3组,而单位质量组织细菌计数低于其他3组。结论鹿茸多肽能够提高皮肤愈合速度,增加组织细胞间连接,加速上皮化生。
英文摘要：
Objective It is to discuss the influence of Pilose antler polypeptide（PAP） on skin wound healing. Methods 48 rats were randomly divided into 4 groups： one control group and three experimental groups, with 12 ones in each group. Skin wound with 5cm × 5cm was established on the back of the rats using vertebral column as the center. Only PAP injection in experimental group 1 ; only external use of PAP in experimental group 2 ; mixed usage of PAP in experimental group 3. The medicine was using once a day and the wound healing was observed in 2,4, 6, 8, 10, 12, 14 days. Wound area was measured, healing area and velocity was calculated on 10th day, amount of bacteria in tissue per unit mass and content of hydroxyproline were also measured. Results Healing area, velocity and containing of hydroxyproline of experimental group 3 were better than that in the other three groups. Amount of bacteria was lower than the other three groups. Conclusion PAP can enhance skin wound healing, increase connection of cells and tissue, accelerate growth of epithelial tissue.
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