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中文摘要：
目的观察甲状腺功能亢进（甲亢）大鼠中枢神经系统Ⅱ型脱碘酶mRNA（D2-mRNA）的表达。方法将Wistar大鼠分为对照组和甲亢组，甲亢组采用40g/L甲状腺素灌胃。连续3周后定量荧光RT-PCR技术分析甲亢大鼠大脑、小脑、海马、脑干和脊髓中D2-mRNA表达的变化。结果甲亢大鼠大脑、小脑、海马、脑干和脊髓的D2-mRNA的表达均被抑制，与对照组比较，分别下调22．21％、45．57％、31．56％、34．79％、85．10％。结论甲亢时大鼠中枢神经系统的D2在转录水平受到抑制，说明D2对中枢神经系统自稳态的调节起着重要的作用。
英文摘要：
Objective To detect the expression of type 2 iodothyronine deiodinase mRNA in hyperthyroid central nervous system. Methods Wister rats were divided into normal group and hyperthyroid group. The expression of type 2 deiodinase in cerebrum, cerebellum, hippocampus, brain stem and spinal cord of hyperthyroid rats was measured by real-time PCR after 3 weeks intragastric administration of 40 g/L tetraiodothyronine for hyperthyroid group. Results At transcriptional level,the expression of type 2 iodothyronine deiodinase was obviously inhibited in cerebrum, cerebellum, hippocampus, brain stem and spinal cord of hyperthyroid rats compared with those of normal control group, decreasing by 22.21%, 45.57%, 31.56%, 34.79% and 85.10%, respectively. Conclusions The type 2 iodothyronine deiodinase in the central nervous system of hyperthyroid rats is inhibited at transcriptional level, indicating that type 2 iodothyronine deiodinase plays an important role in adjusting the homeostasis of central nervous system.
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