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中文摘要：
目的 观察过量碘性脂代谢紊乱的适宜的硒干预剂量。方法 80只Balb／c小鼠分为8组：正常组、高碘组（饮水含碘3000μg／L）和6个补硒组（饮水舍碘3000μg／L，硒分别为0．1、0．2、0．3、0．4、0．5、0．75mg／L），共喂养16周。放射免疫法测定甲状腺激素水平，测定血清和肝脏甘油三酯、胆固醇含量。结果 与正常组比较，高碘组血清总胆固醇、肝脏总胆固醇、甘油三酯升高。而补充0．2mg／L硒组上述指标与正常组差异无显著性。结论 补充0．2mg／L硒可有效干预过量碘引起的脂代谢紊乱。
英文摘要：
Objective To explore the effect of selenium supplement on the disordered lipid metabolism induced by the overdose of iodine in mice. Methods The 80 Balb/c mice were randomly divided into eight groups, the normal control group, the high iodine group（drunk the water containing iodine 3000μg/L） and six selenium groups （drunk the water containing iodine 3000μg/L and selenium 0. 1, 0. 2, 0. 3,0.4, 0. 5,0.75mg/L）. The total cholesterol and tfiglycefide in serum and liver were determined. Results The total cholesterol in serum, the total cholesterol and triglyeefide in liver of high-iodine group increased significantly compared with normal control group. There is no difference between normal control group and the group drunk the water contained 0.2mg/L selenium. Conclusion It suggests that it is an effective intervention dosage to drunk water containing 0.2mg/L selenium.
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