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中文摘要：
目的 观察不同剂量高碘摄入对小鼠胚胎发育的影响,为评价高碘的生殖毒性提供理论依据.方法 BABL/C小鼠195只,雌雄2：1,按体重将动物随机分为6组,对照组45只动物,其它每组30只动物.通过饮水中给予不同剂量的高碘（1 500、3 000、6 000、12 000和24 000μg/L）,4个月后合笼,观察长期高碘摄入对小鼠胚胎发育的影响.结果 高碘组母鼠血清总四碘甲腺原氨酸（total tetraiodothyronine,TT4）水平升高,总三碘甲腺原氨酸（total triiodothyronine,TT3）水平降低,从3 000μg/L开始与对照组差异有统计学意义.平均胎盘重从3 000 μg/L组以上均明显低于阴性对照组.高碘组的吸收胎率和死胎率明显升高,并且呈剂量-效应关系（r=0.167,P＜0.05）.高碘组骨骼畸形发生率升高,从3 000μg/L开始差异有统计学意义,并且呈剂量-效应关系（r=0.80,P＜0.05）.结论 长期高碘摄入具有胚胎发育毒性,主要表现为胚胎的骨骼畸形.该实验条件下,高碘所致胚胎发育毒性的阈剂量为3 000μg/L（即0.75 mg/kg）.
英文摘要：
Objective To investigate the embryo toxicity induced by excessive iodine intake in mice. Methods 195 Balb/C mice （female： male = 2：1 ） were given different doses of iodine at the levels of 0 （sterile water）, 1500, 3 000, 6 000, 1 2000 and 24 000μg/L in drinking water for four months, then were mated and the developmental toxicity were evaluated. Results Serum total tetraiodothyronine level in 3 000μg/L or above groups increased significantly and total triodothyronine level decreased. Average placenta weight was marked lower in 3 000 μg/L or above groups than that in negative control group. Excessive iodine intake resulted in an increased rate of fetal resorption and a decreased number of live fetuses. The incidence of skeleton anomalies increased dose-dependently in excessive iodine intake groups（ r = 0.80, P 〈 0.05）. Conclusion Excessive iodine intake induces embryo toxicity, especially skeletal malformation. The threshold level of iodine induced embryo toxicity in this study is 3 000μg/L （0.75 mg/kg）.
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