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不同孕期孕妇血清总蛋白和白蛋白水平的比较研究

ISSN号：1006-1703
期刊名称：《标记免疫分析与临床》
时间：0
分类：R644[医药卫生—临床医学;医药卫生—外科学]
作者机构：[1]陆军总医院263临床部检验科,北京101149, [2]陆军总医院263临床部妇产科彩超室,北京101149, [3]陆军总医院263临床部妇产科,北京101149
相关基金：国家高技术研究发展计划（863计划）（2014AA022304）

作者：李洋[1], 郭学青[1], 夏梦岩[1], 高宏伟[1], 路路[1], 王晓娜[2], 刘鑫丽[3]

关键词：血清总蛋白, 白蛋白, 孕期, 孕妇年龄, Serum Total Protein, Albumin, Pregnancy, Pregnant women age

中文摘要：

目的对正常妊娠不同孕期女性血清总蛋白和白蛋白水平进行观察和分析。方法选取来我院体检并建档的健康孕妇735例,将其分为孕早、中、晚期及临产后组;以同期来院体检的健康同年龄段女性178例为非妊娠对照组,测定血清总蛋白和白蛋白浓度,并进行比较。结果正常妊娠女性血清总蛋白在孕中、晚期及临产后与同年龄段非妊娠女性对照组比较,均低于对照组,且随着孕周的增加而不断降低,差异有统计学意义（P〈0.05）;血清白蛋白在孕早、中、晚期及临产后与同年龄段非妊娠女性对照组比较,均低于对照组,且随着孕周的增加而变化显著,差异有统计学意义（P〈0.05）;各年龄组中同一年龄组血清总蛋白和白蛋白在孕早、中、晚期及临产后之间分别两两比较差异均有统计学意义（P〈0.05）。结论正常妊娠女性在不同孕期血清总蛋白和白蛋白水平有一定差异,且随着孕周的递增而差异显著,妊娠女性应定期检测血清蛋白水平,对优生优育有着重要临床的意义。

英文摘要：

Objective To observe and analyse the levels of serum total protein and albumin in different pregnant women during pregnancy. Methods 735 healthy pregnant women were divided into early,middle,late pregnancy and after labor groups who were archived after heathy examination in our hospital. In the same period 178 cases of non-pregnant women who were within the same age stage and also did healthy examination in our hospital were selected as controls. Then the concentration of serum total protein and albumin in all observers was measured and compared. Results The level of serum total protein was compared between the normal pregnant women during groups of early,middle,late pregnancy or after labor groups with non-pregnancy group of the same age. The data show ed that the level of serum total protein was significantly lower than control,which was correlated with gestational age（P〈0. 05）. It was also show ed that the level of serum albumin in pregnant early,middle,late and after labor was lower than that in nonpregnant women within the same age stage group（P〈0. 05）,which is more significant correlated with increasing gestational age. In each age group,there was a significant difference when comparing serum total protein and albumin in pregnant early,middle,late and after labor respectively between pairw ise comparisons（P〈0. 05）. Conclusion We found that the level of serum total protein and albumin changed during pregnancy,which significance is relative to gestational age. It might have important clinical significance to test periodically serum protein level for prenatal and postnatal care.

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