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中文摘要：
目的：探讨血清胱抑素C（Cys-C）、叶酸（FA）、维生素B12（VitB12）含量水平与慢性肾脏病（CKD）患者心血管并发症的关系。方法：86例CKD患者根据有无心血管并发症分为无心血管并发症组47例和有心血管并发症组39例。两组均采用胶乳免疫比浊法测定血清Cys-C浓度和采用电化学发光法检测血清叶酸、维生素B12水平。结果：CKD患者有心血管并发症组血清Cys-C高于无心血管并发症组（P〈0.01）,而血清FA和VitB12水平低于无心血管并发症组（P〈0.01）。多因素回归分析显示,高血清Cys-C血症和低FA和VitB12血症是CKD患者心血管并发症的危险因素。结论：CKD患者血清Cys-C、FA、VitB12水平能敏感预测心血管并发症,血清Cys-C、FA、VitB12水平与肌酐明显相关。
英文摘要：
Objective： To investigate the serum cystatin C （Cys-C）, folic acid （FA）, vitamin B12 （Vit B12） level in chronic kidney disease （CKD） between patients with cardiovascular complications. Methods： 86 patients with CKD were randomly divided into two groups according to the risk factors of cardiovascular complications. There were no cardiovascular complications in the group of 47 patients and cardiovascular complications in the treatment group （n=39）. Two groups of patients were determined by latex immunoassay turbidimetry serum Cys-C concentrations and serum levels of folic acid, vitamin B12 levels were detected by electrochemilumi-nescence. Results： The serum Cys-C of patients with cardiovascular complications in CKD group was higher than that of non vascular complication group （P〈0.01）, while the levels of serum FA and VitB12 were lower than those of non vascular complication group （P〈0.01）. Multivariate regression analysis showed that high serum Cys-C and low FA and Vit B12 were risk factors of cardiovascular complications in patients with CKD. Conclusion： serum Cys-C, FA and Vit levels in patients with B12 can be used to predict cardiovascular complications. Serum Cys-C, FA, Vit B12 levels are significantly correlated with creatinine levels in patients with CKD.
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