中文摘要：

目的 探讨血清铁蛋白（SF）与动脉粥样硬化诊断指标的相关性。方法 选取2013年1月至2014年12月就诊的180例动脉粥样硬化高危患者作为研究对象,根据患者是否有动脉粥样硬化分为两组：有颈动脉粥样硬化102例设为观察组,无颈动脉粥样硬化78例设为对照组。对比分析两组血浆血清SF、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、甘油三脂（TG）、低密度脂蛋白胆固醇（LDL-C）、超敏C反应蛋白（CRP）,以及与SF的相关性。根据SF值将观察组患者分为血清SF升高组（SF〉300 ng/ml）和血清SF正常组（20~300 ng/ml）,分析患者内膜中层厚度（IMT）、斑块评分、颈动脉粥样硬化斑块总积分（Crouse积分）,以及与SF的相关性。结果 颈动脉粥样硬化硬化患者TG、TC、LDL-C、CRP、SF等浓度明显高于非颈动脉粥样硬化患者,HDL-C明显低于非颈动脉粥样硬化患者,差异均有统计学意义（P〈0.05）;血清SF浓度与TC、TG、LDL-C、CRP呈正相关（P均〈0.05）,血清SF浓度与HDL-C浓度呈负相关（P〈0.05）;血清SF升高组患者IMT、斑块评分、Crouse积分明显高于血清SF正常组患者,差异均有统计学意义（P〈0.05）;血清铁蛋白浓度与IMT、斑块评分、Crouse积分呈正相关。结论 血清SF与动脉粥样硬化的发生发展有密切联系,与动脉粥样硬化诊断指标如TC、TG、LDL-C呈正相关,与HDL-C浓度呈负相关。

英文摘要：

Objective To investigate the relationship between the serum ferritin（SF） and atherosclerosis diagnosis index correlation studies.Methods A total of 180 cases of patients at high risk of atherosclerosis from January 2013 to December 2014 were divided into two groups according to whether the patients with atherosclerosis.102 cases of carotid artery atherosclerosis were considered as observation group,78 cases of carotid artery atherosclerosis were considered as control group.Blood SF,total cholesterol（TC）,high density lipoprotein cholesterol（HDL- C）,triglycerides（TG）,low density lipoprotein cholesterol（LDL- C）,c- reactive protein（CRP） was analyzed between two groups.The observation group was divided into two groups according to the serum level of SF,〉 300 ng/ml group and normal group（20-300 ng/ml） group.The IMT,plaque score,Crouse score was analyzed,and the correlation with SF were analyzed.Results The concentration of TG,TC,LDL- C and CRP of patients with carotid artery atherosclerosis sclerosis were respectively（2.84 ±0.97） mmol/L,（5.32 ±1.35） mmol/L,（3.24 ±0.87） mmol/L,（4.63 ± 1.94）mmol/L,（438.05 ± 171.43） ng/ml,which was significantly higher than those in patients with carotid atherosclerosis.The concentration of HDL-C was（0.97 ±0.27） mmol/L,which was obviously lower than those of patients with carotid atherosclerosis,which are statistically significant differences（P〈 0.05）.Serum ferritin concentration was positively correlated with TC,TG,LDL- C（P〈 0.05）,serum ferritin concentrations and negatively correlated with HDL- C concentration（P 〈0.05）.Patients with elevated serum ferritin groups IMT,plaque score,Crouse integral was significantly higher than normal group of patients,serum ferritin difference had statistical significance（P 〈0.05）.Serum ferritin concentration was positively correlated with IMT,plaque score and Crouse score（P 〈0.05）.Conclusion The serum ferritin is closely related with the incidence of atherosclerosis