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中文摘要：
目的探讨慢性乙型肝炎患者血清超氧化物歧化酶的检测以及与干扰素受体表达的关系。方法选取我院2014年1月至2015年1月收治的60例乙型肝炎患者作为观察组,另选60例健康人作为对照组。两组受试者在实验开始时空腹采集肘静脉血清SOD、血生化。随访受试者,督促其在1、3、6、12月复测本研究中所涉及指标,并记录每位受试者病例特点、临床相关危险因素。结果观察组与对照组比较,血清SOD的活力显著降低（P〈0.05）;观察组血清SOD的活性与血清ALT呈现负相关的关系（r=-0.541,P〈0.05）,SOD的活性与肝组织病例验证程度呈负相关（r=-0.431,P〈0.05）。结论超氧化物歧化酶是超氧阴离子自由基的特效专一抑制酶,利用清除氧自由基在慢性乙肝中起到抗氧化损伤作用。缺乏超氧化物歧化酶,可能是造成慢性乙型肝炎患者肝纤维化加重的原因。对于慢性乙型肝炎患者,在免疫耐受期和病毒低复制期时,超氧化物歧化酶可以抑制外周血单个核细胞干扰素受体αmRNA的表达。
英文摘要：
Objective： To investigate the serum superoxide dismutase（ SOD） of patients with chronic hepatitis b detection and relations with interferon receptor expression. Methods： To choose the hospital between January 2014 and January2015,60 patients with hepatitis b,as an observer,choose 60 cases of healthy people as the normal control group. At the beginning of the two groups of subjects in the experimental was collected on an empty stomach venous serum SOD,blood biochemistry. Follow-up of subjects,to urge the 1,3,6,12 month indicators involved in the survey of this study,and record each subject characteristics,clinical cases related risk factors. Results： The observation group compared with control group,serum SOD vigor significantly reduced（ P〈0. 05）; Observation group serum SOD activity and serum ALT present negative correlation relationship（ r = 0. 541,P〈0. 05）,the activity of SOD and negatively correlated to the degree of liver tissue case validation（ r = 0. 431,P〈0. 05）. Conclusions： Superoxide dismutase（ SOD） is a special effects on superoxide anion inhibit enzyme specificity,using the removal of oxygen free radical oxidation damage effect in chronic hepatitis b. Lack of superoxide dismutase（ SOD）,may be the cause of chronic hepatitis b patients with liver fibrosis is aggravating.For chronic hepatitis b patients,stage in immune tolerance and low viral replication,superoxide dismutase（ SOD） can inhibit the peripheral blood mononuclear cells（ alpha interferon receptor mRNA expression.
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