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1型和2型糖尿病患者血清HCY水平及其与糖尿病微血管并发症的关系研究

ISSN号：1005-930X
期刊名称：《广西医科大学学报》
时间：0
分类：R587.1[医药卫生—内分泌;医药卫生—临床医学;医药卫生—内科学]
作者机构：广西医科大学第一附属医院检验科,南宁530021
相关基金：国家高技术研究发展计划（863计划）资助项目（No.2014AA022304）

关键词： 1型糖尿病, 2型糖尿病, 同型半胱氨酸, 糖尿病微血管并发症, type 1 diabetes, type 2 diabetes, homocysteine, diabetic microvascular complications

中文摘要：

目的：观察1型和2型糖尿病（T1DM、T2DM）患者血清中同型半胱氨酸（HCY）的水平，并分析其与糖尿病微血管并发症的关系。方法：选取2015年9月至2016年4月广西医科大学第一附属医院收治的26例T1DM患者（T1DM组）及114例T2DM患者（T2DM组），根据并发症发生情况又分为3个亚组：DPN组、DR组和DN组。另选取同期在本院接受体检的55例健康志愿者作为健康对照组。采用酶循环法检测各组血清中HCY的水平。结果：T1DM组血清HCY水平低于健康对照组和T2DM组，差异均有统计学意义（均P〈0．05）。T2DM组血清HCY水平与健康对照组比较，差异无统计学意义（P〉0．05）。TIDM伴DPN组的血清HCY水平稍高于单纯TIDM组，但仍低于健康对照组，差异均无统计学意义（均P〉0．05）。在T2DM各亚组中，T2DM伴DN组血清HCY水平明显高于单纯T2DM组及健康对照组，差异有统计学意义（P〈0．05）；T2DM伴DPN组、T2DM伴DR组血清HCY水平均高于单纯T2DM组及健康对照组，但差异无统计学意义（P〉0．05）。结论：T2DM患者的血清HCY水平明显高于T1DM，T2DM增高的血清HCY水平与其微血管并发症的发生有关，血清HCY水平增高是T2DM合并DN的危险因素之一，定期监测T2DM患者血清HCY水平有助于了解疾病进程及有效预防T2DM微血管并发症的发生。

英文摘要：

Objective：To observe the difference of serum homocysteine （HCY） level between type 1 and type 2 diabetes （T1DM and T2DM） patients, and to investigate the association between HCY level and diabetic microvascular complications. Methods： From September 2015 to April 2016, 26 T1DM patients （TIDM group） and 114 T2DM patients （T2DM group） treated in our hospital were selected and were subdivided into diabetic peripheral neuropathy （DPN） and diabetic nephropathy （DN） groups according to the occurrence of complications. 55 healthy subjects were also selected as the healthy control group. The level of HCY in serum was measured by the circulating enzymatic method. Results：The serum HCY level in T1DM group was statistically lower than those in T2DM group and healthy control group （ P d0.05）, and no significant difference between T2DM group and healthy control group （ P 〉0.05）. T1DM patients combined with DPN had higher level of HCY than only T1DM ones, but still lower than the healthy controls（ P〉 0.05）. The HCY level of T2DM patients combined with DPN or DR was a little higher than only T2DM ones and healthy controls （ P 〉0.05）. Conclusion：The HCY level in T2DM patients was higher than that in T1DM ones. The elevated HCY level was associated with the occurrence of microvascular complications and it could be one of the risk factors for DN in T2DM patients. Regular monitoring of HCY level may help to understand the disease process and prevent T2DM microvascular complications.

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